ArticleWorld journal of surgical oncology2014
High expression of periostin is dramatically associated with metastatic potential and poor prognosis of patients with osteosarcoma.
Article in World journal of surgical oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- LncRNAs as potential prognosis/diagnosis markers and factors driving drug resistance of osteosarcoma, a review.Frontiers in endocrinology · 2024Review
- Periostin promotes the proliferation and metastasis of osteosarcoma by increasing cell survival and activates the PI3K/Akt pathway.Cancer cell international · 2022Article
- Role of Periostin Expression in Canine Osteosarcoma Biology and Clinical Outcome.Veterinary pathology · 2021Article
- Article
- Zinc promotes cell apoptosis via activating the Wnt-3a/β-catenin signaling pathway in osteosarcoma.Journal of orthopaedic surgery and research · 2020Article
- Distinct expression pattern of periostin splice variants in chondrocytes and ligament progenitor cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma.Cell death & disease · 2018Review
- Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin.Nature communications · 2018Article
- Periostin expression in neoplastic and non-neoplastic diseases of bone and joint.Clinical sarcoma research · 2018Article
- Biological analysis of cancer specific microRNAs on function modeling in osteosarcoma.Scientific reports · 2017Article
- Increased Six1 expression is associated with poor prognosis in patients with osteosarcoma.Oncology letters · 2017Article
- Periostin is required for matricellular localization of CCN3 in periodontal ligament of mice.Journal of cell communication and signaling · 2017Article
- Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma.BioMed research international · 2017Article
- Identification of extracellular vesicle-borne periostin as a feature of muscle-invasive bladder cancer.Oncotarget · 2016Article
- Vitronectin significantly influences prognosis in osteosarcoma.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
backgroundRecent studies have found that periostin (PN), as a kind of secreted glycoprotein, is closely related to the metastatic potential and prognosis of many kinds of tumors. This study aimed to examine the expression of PN in patients with osteosarcoma and explore the relationship of PN expression with clinicopathologic factors and prognosis.
methodsPN was detected by histopathological and immunohistochemical methods in 62 cases of osteosarcoma and 62 of osteochondroma. Detailed pathological and clinical data were collected by reviewing medical records.
resultsThe results showed that increased PN protein expression was prevalent in osteosarcoma and was significantly associated with pathologic subtype (P =0.000), tumor size (P =0.016) and Enneking stage (P =0.047). Additionally, expression of PN was found to be an independent prognostic factor in osteosarcoma patients. High expression of PN protein is closely correlated to the tumor progression and poor survival of osteosarcoma.
conclusionsOur data suggest that PN is a promising biomarker for identifying individuals with poor prognostic potential and suggests its possible use as a prognostic marker in patients with osteosarcoma.
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