ArticleThe Journal of cell biology1989
The role of cyclin B in meiosis I.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 241 citations in OpenAlex.
- Molecular cloning and characterization of a cyclin B gene on the ovarian maturation stage of black tiger shrimp (Penaeus monodon).Molecular biology reports · 2023Article
- Identifying potential maternal genes of Bombyx mori using digital gene expression profiling.PloS one · 2018Article
- The potential role of As-sumo-1 in the embryonic diapause process and early embryo development of Artemia sinica.PloS one · 2014Article
- Localization and dynamics of Cdc2-cyclin B during meiotic reinitiation in starfish oocytes.Molecular biology of the cell · 2003Article
- Residual Cdc2 activity remaining at meiosis I exit is essential for meiotic M-M transition in Xenopus oocyte extracts.The EMBO journal · 2000Article
- Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction.The EMBO journal · 2000Article
- Cell cycle-regulated proteolysis of mitotic target proteins.Molecular biology of the cell · 1999Article
- Cytoplasmic polyadenylation elements mediate masking and unmasking of cyclin B1 mRNA.The EMBO journal · 1999Article
- The clam 3' UTR masking element-binding protein p82 is a member of the CPEB family.RNA (New York, N.Y.) · 1999Article
- Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 1998Review
- Cap ribose methylation of c-mos mRNA stimulates translation and oocyte maturation in Xenopus laevis.Nucleic acids research · 1998Article
- A dependent pathway of cytoplasmic polyadenylation reactions linked to cell cycle control by c-mos and CDK1 activation.Molecular biology of the cell · 1997Article
- Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Cell cycle regulation in Aspergillus by two protein kinases.The Biochemical journal · 1996Review
- Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes.The EMBO journal · 1995Article
- Requirement for phosphorylation of cyclin B1 for Xenopus oocyte maturation.Molecular biology of the cell · 1995Article
- Members of the NAP/SET family of proteins interact specifically with B-type cyclins.The Journal of cell biology · 1995Article
- Article
- Oocyte activation and passage through the metaphase/anaphase transition of the meiotic cell cycle is blocked in clams by inhibitors of HMG-CoA reductase activity.The Journal of cell biology · 1995Article
- The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.Molecular biology of the cell · 1995Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In clams, fertilization is followed by the prominent synthesis of two cyclins, A and B. During the mitotic cell cycles, the two cyclins are accumulated and then destroyed near the end of each metaphase. Newly synthesized cyclin B is complexed with a small set of other proteins, including a kinase that phosphorylates cyclin B in vitro. While both cyclins can act as general inducers of entry into M phase, the two are clearly distinguished by their amino acid sequences (70% nonidentity) and by their different modes of expression in oocytes and during meiosis. In contrast to cyclin A, which is stored solely as maternal mRNA, oocytes contain a stockpile of cyclin B protein, which is stored in large, rapidly sedimenting aggregates. Fertilization results in the release of cyclin B to a more disperse, soluble form. Since the first meiotic division in clams can proceed even when new protein synthesis is blocked, these results strongly suggest it is the fertilization-triggered unmasking of cyclin B protein that drives cells into meiosis I. We propose that the unmasking of maternal cyclin B protein allows it to interact with cdc2 protein kinase, which is also stored in oocytes, and that the formation of this cyclin B/cdc2 complex generates active M phase-promoting factor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.