Evidence map›Paper›PMID 25224078›Full record

ReviewAnnals of biomedical engineering2015

A systems view of risk factors for knee osteoarthritis reveals insights into the pathogenesis of the disease.

Thomas P Andriacchi, Julien Favre, J C Erhart-Hledik, Constance R Chu

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of biomedical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07262931 (Effect Of Sensory Motor Training Versus Resistance Training On Improving Pain, Balance And Functional Activities Among Individuals With Knee Osteoarthritis), which is not on this map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07262931 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect Of Sensory Motor Training Versus Resistance Training On Improving Pain, Balance And Functional Activities Among Individuals With Knee Osteoarthritis

TypeinterventionalSponsorLahore University of Biological and Applied SciencesRan2025 to 2026Enrolled52ConditionsKnee OsteoarthristisArmsSensory motor training, Resistance Training
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Gait Biomechanical Profiles Following Anterior Cruciate Ligament Reconstruction in Sexually-Immature Pediatrics.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Impact of Abnormal Mechanical Stress on Chondrocyte Death in Osteoarthritis.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  13. Review
  14. Osteoarthritis.Nature reviews. Disease primers · 2025
    Review
  15. Reproducibility of Quantitative Double-Echo Steady-State TJournal of magnetic resonance imaging : JMRI · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Thomas P AndriacchiDepartment of Mechanical Engineering, Stanford University, Durand 227, Stanford, CA, 94305, USA, tandriac@stanford.edu.
Julien Favre
J C Erhart-Hledik
Constance R Chu
Stanford University · USUniversity of Lausanne · CHVA Palo Alto Health Care System · US

Funding

Enhanced Clinical Diagnosis of Early OsteoarthritisR01AR052784 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHU, CONSTANCE R · 2006 to 2015
$4.1M
Anterior Cruciate Ligament Reconstruction and the Initiation of OsteoarthritisR01AR039421 · NIAMS · STANFORD UNIVERSITY · PI ANDRIACCHI, THOMAS P · 1988 to 2013
$3.3M
NIAMS NIH HHS R01 AR039421NIAMS NIH HHS R01 AR052784
6 · The paper itself

Abstract

Early detection of osteoarthritis (OA) remains a critical yet unsolved multifaceted problem. To address the multifaceted nature of OA a systems model was developed to consolidate a number of observations on the biological, mechanical and structural components of OA and identify features common to the primary risk factors for OA (aging, obesity and joint trauma) that are present prior to the development of clinical OA. This analysis supports a unified view of the pathogenesis of OA such that the risk for developing OA emerges when one of the components of the disease (e.g., mechanical) becomes abnormal, and it is the interaction with the other components (e.g., biological and/or structural) that influences the ultimate convergence to cartilage breakdown and progression to clinical OA. The model, applied in a stimulus-response format, demonstrated that a mechanical stimulus at baseline can enhance the sensitivity of a biomarker to predict cartilage thinning in a 5 year follow-up in patients with knee OA. The systems approach provides new insight into the pathogenesis of the disease and offers the basis for developing multidisciplinary studies to address early detection and treatment at a stage in the disease where disease modification has the greatest potential for a successful outcome.

Indexed as

Models, BiologicalHumansOsteoarthritis, KneeRisk Factors

Identifiers

PMID25224078
PMCPMC4340713
OpenAlexW2063815157

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.