ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2014
The use of a multiplex real-time PCR assay for diagnosing acute respiratory viral infections in children attending an emergency unit.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Etiology and Clinical Manifestations of Acute Respiratory Infections in Pediatric Patients: A Retrospective Study in Moscow, Russia.Diseases (Basel, Switzerland) · 2026Article
- Clinical Relevance of Multiplex PCR for Respiratory Pathogens in Hospitalized Adults with Influenza-Like Illness.Journal of clinical practice and research · 2026Article
- Article
- Respiratory pathogens in infants and young children with acute respiratory illness: a prospective cohort study, China, 2023-2024.Frontiers in public health · 2025Article
- Viral Identification Using Multiplex Polymerase Chain Reaction Testing Does Not Reduce Antibiotic Prescribing in Paediatric Intensive Care Units.Microorganisms · 2023Article
- Viral Etiology and Clinical Characteristics of Acute Respiratory Tract Infections in Hospitalized Children in Southern Germany (2014-2018).Open forum infectious diseases · 2023Article
- Antibiotic Prescribing Patterns for Outpatient Pediatrics at a Private Hospital in Abu Dhabi: A Clinical Audit Study.Antibiotics (Basel, Switzerland) · 2022Article
- Article
- Distribution of respiratory viruses: Evaluation of multiplex PCR results of 3074 patients.Northern clinics of Istanbul · 2022Article
- Epidemiologic and clinical characteristics of human bocavirus infection in infants and young children suffering with community acquired pneumonia in Ningxia, China.Virology journal · 2021Article
- Cytokine expression patterns in hospitalized children with Bordetella pertussis, Rhinovirus or co-infection.Scientific reports · 2021Article
- The epidemiologic and clinical features of viral agents among hospitalized children with lower respiratory tract infections.Turk pediatri arsivi · 2020Article
- Combining Procalcitonin and Rapid Multiplex Respiratory Virus Testing for Antibiotic Stewardship in Older Adult Patients With Severe Acute Respiratory Infection.Journal of the American Medical Directors Association · 2020Article
- Molecular Diagnosis of Pneumonia Using Multiplex Real-Time PCR Assay RespiFinder® SMART 22 FAST in a Group of Moroccan Infants.Advances in virology · 2020Article
- Severe Sepsis in Pediatric Liver Transplant Patients: The Emergence of Multidrug-Resistant Organisms.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2019Article
- Etiology and characteristics of community-acquired pneumonia in an influenza epidemic period.Comparative immunology, microbiology and infectious diseases · 2019Article
- Epidemiology and seasonality of acute respiratory infections in hospitalized children over four consecutive years (2012-2016).Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2018Article
- Epidemiologic Analysis of Respiratory Viral Infections Mainly in Hospitalized Children and Adults in a Midwest University Medical Center After the Implementation of a 14-Virus Multiplex Nucleic Acid Amplification Test.American journal of clinical pathology · 2017Article
- Assessment of the Usefulness of Multiplex Real-Time PCR Tests in the Diagnostic and Therapeutic Process of Pneumonia in Hospitalized Children: A Single-Center Experience.BioMed research international · 2017Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of a multiplex molecular technique to identify the etiological pathogen of respiratory viral infections might be a support as clinical signs are not characteristic.
objectivesThe aim of the study was to evaluate a multiplex molecular real-time assay for the routine diagnosis of respiratory viruses, to analyze the symptoms associated with the pathogens detected and to determine the spread of virus during the period. STUDY
designRespiratory samples were collected from children presenting with respiratory symptoms and attending the emergency unit during the 2010-2011 winter seasons. Samples were tested with the multiplex RespiFinder(®) 15 assay (PathoFinder™) which potentially detects 15 viruses.
results857 (88.7%) of the 966 samples collected from 914 children were positive for one (683 samples) or multiple viruses (174 samples). The most prevalent were the respiratory syncytial virus (39.5%) and the rhinovirus (24.4%). Influenza viruses were detected in 139 (14.4%) samples. Adenovirus was detected in 93 (9.6%) samples, coronaviruses in 88 (9.1%), metapneumovirus in 51 (5.3%) and parainfluenzae in 47 (4.9%). Rhinovirus (40%) was the most prevalent pathogen in upper respiratory tract infections while respiratory syncytial virus (49.9%) was the most prevalent in lower respiratory tract infections. Co-infections were associated with severe respiratory symptoms.
conclusionThe multiplex assay detected clinically important viruses in a single genomic test and thus will be useful for detecting several viruses causing respiratory tract disorders.
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