ArticleAmerican journal of obstetrics and gynecology2015
Inflammatory predictors of neurologic disability after preterm premature rupture of membranes.
Article in American journal of obstetrics and gynecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Risk factors for premature rupture of membranes in pregnant women: a systematic review and meta-analysis.BMJ open · 2024Pooled it
- Fetal and Neonatal Effects of N-Acetylcysteine When Used for Neuroprotection in Maternal Chorioamnionitis.The Journal of pediatrics · 2016Trial
- Systemic inflammatory mediators and neurodevelopmental outcomes in term infants: a retrospective cohort study.BMC pediatrics · 2026Article
- Evaluation of Preventive Antibiotic Regimens for Preterm Premature Rupture of Membranes: Efficacy and Safety of Triple Therapy versus Cephalosporin Monotherapy.Drug design, development and therapy · 2026Article
- Dietary Habits and Their Influence on the Microbiome and Mental Health in Adolescents.Nutrients · 2025Review
- Quantification of intra-amniotic inflammation in late preterm prelabour rupture of membranes.Scientific reports · 2025Article
- Associations of Placental Inflammation and Oxidative Stress Biomarkers with Glucolipid Metabolism in Children: A Birth Cohort Study in China.Journal of the American Heart Association · 2024Article
- Does Preterm Prolonged Rupture of Membranes Increase the Risk of Needing Invasive Respiratory Support? A Retrospective Single-Centre Study.Children (Basel, Switzerland) · 2024Article
- Maternal Exposure to Environmental Air Pollution and Premature Rupture of Membranes: Evidence from Southern China.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Frontiers in the Etiology and Treatment of Preterm Premature Rupture of Membrane: From Molecular Mechanisms to Innovative Therapeutic Strategies.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Pain/Stress, Mitochondrial Dysfunction, and Neurodevelopment in Preterm Infants.Developmental neuroscience · 2024Article
- Placental inflammatory cytokines mRNA expression and preschool children's cognitive performance: a birth cohort study in China.BMC medicine · 2023Article
- Intra-amniotic inflammation in the mid-trimester of pregnancy is a risk factor for neuropsychological disorders in childhood.Journal of perinatal medicine · 2023Article
- The Role of the Interleukin-1 Family in Complications of Prematurity.International journal of molecular sciences · 2023Review
- Relationship between placental pathology and neonatal outcomes.Frontiers in pediatrics · 2023Article
- Neurological implications of antenatal corticosteroids on late preterm and term infants: a scoping review.Pediatric research · 2022Article
- Neonatal outcomes in women with preterm premature rupture of membranes at periviable gestational age.Scientific reports · 2022Observational
- Proteomic profiling of human amnion for preterm birth biomarker discovery.Scientific reports · 2021Article
- Concentrations of fat-soluble nutrients and blood inflammatory compounds in mother-infant dyads at birth.Pediatric research · 2021Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThe maternal-fetal inflammatory response contributes to both preterm premature rupture of membranes (PPROM) and adverse neurological outcomes. Additionally, cytokines associated with fetal placental inflammation can be detrimental to brain development regardless of inciting infection. We investigated whether differential patterns of cytokine markers in maternal and fetal plasma samples reflect subtypes of placental inflammation and neurological outcomes at 6 months in infants born to mothers with PPROM. STUDY
designWithin a prospective cohort study of 25 women with PPROM, plasma cytokines (interleukin [IL]-1β, IL-6, IL-8, and tumor necrosis factor-α) were measured by enzyme-linked immunosorbent assay from maternal blood samples at rupture and delivery, and from fetal umbilical cord blood samples. Patterns of cytokine expression were correlated with specific placenta pathologies. Infants underwent cranial ultrasound after birth and standardized neurological examinations at 6 months' corrected gestational age. Predictors of inflammation and adverse neurological outcome were assessed by logistic regression, adjusting for gestational age at birth.
resultsInflammation of the fetal side of the placenta was associated with elevated maternal IL-6 and IL-8 at delivery and fetal IL-1β, IL-6, IL-8, and tumor necrosis factor-α. Worse neurological outcome at 6 months was associated with inflammation of the fetal side of the placenta and shorter duration from rupture of membrane to delivery, independent of gestational age at birth or cranial ultrasound results.
conclusionOur findings support the connection between fetal inflammation with adverse neurological outcome with PPROM, regardless of cranial ultrasound results. Further longitudinal studies are needed to adequately examine these patterns, and will aid in risk assessment and intervention strategies.
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