Trial reportThe Indian journal of medical research2014
Role of 13C methacetin breath test for non invasive staging of liver fibrosis in patients with chronic hepatitis C.
Trial report in The Indian journal of medical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A deep learning approach for detecting liver cirrhosis from volatolomic analysis of exhaled breath.Frontiers in medicine · 2022Article
- Dynamics of serum α-fetoprotein in viral hepatitis C without hepatocellular carcinoma.Experimental and therapeutic medicine · 2021Article
- Management of acute intradialytic cardiovascular complications: Updated overview (Review).Experimental and therapeutic medicine · 2021Review
- Infection with hepatitis C virus in hemodialysis patients: An overview of the diagnosis and prevention rules within a hemodialysis center (Review).Experimental and therapeutic medicine · 2020Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
objectivesThe development and evaluation of non invasive tests to assess liver fibrosis have been an active field of research. The present study was carried out to evaluate the role of 13C-methacetin breath test 13C-MBT) as a non invasive tool for liver fibrosis staging in patients with chronic hepatitis C (CHC).
methods13C-Methacetin breath test was performed in 115 patients with CHC histologically proven and in 55 healthy controls. All patients and controls underwent routine liver function tests. The CHC patients underwent histological assesment of liver by percutaneous liver biopsy. The correlation between the 13C-methacetin breath test and liver biopsy was tested using Kendall's rank correlation coefficients. The overall validity was expressed as area under receiver operating characteristic curve (AUROC) with 95%CI.
resultsDelta over baseline values (DOB) of CHC patients at 20 min were significantly reduced compared with control (16. 2 vs. 21. 06%, p <0.001). There were also significant differences between CHC patients and controls as regard the metabolization speed (dose/h at 20 min (17.80 vs 28.6, p <0.001) and metabolization capacity (cumulative recovery after 60 min (13.8 vs 20.4 p <0.001). The best 13C-MBT parameter correlated with fibrosis was DOB at 20 min (r = -0.596). The optimal cut-off for the diagnosis of advanced fibrosis (F ≥ 3) was 15.2 per cent, with AUROC = 0.902, 95%CI: (0.851-0.938), a sensitivity of 82 per cent and a specificity of 80 per cent. DOB at 20 min predicted even better cirrhosis: AUROC = 0.932 95 per cent CI = 0.901-0.953, a sensitivity of 96 per cent and a specificity of 92 per cent. INTERPRETATION &
conclusionsBased on our findings the 13C-methacetin breath test appears to be a promising tool to identify CHC patients with advanced fibrosis and to replace liver biopsy. Further studies need to be done to assess its potential to be used in regular clinical practice.
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25222787PMC4181145What OpenQuestion holds
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