ArticleThe Journal of clinical endocrinology and metabolism2014
Bone mass and hormone analysis in patients with spinal cord injury: evidence for a gonadal axis disruption.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Endocrinological and inflammatory markers in individuals with spinal cord injury: A systematic review and meta-analysis.Reviews in endocrine & metabolic disorders · 2022Pooled it
- Different approach to bone mineral density in non-traumatic spinal cord injury: a comparison with traumatic spinal cord injury.Journal of rehabilitation medicine · 2026Article
- Bone mineral density after spinal cord injury: assessment of hip and knee measurements.Journal of bone and mineral metabolism · 2025Article
- The use of alkaline phosphatase as a bone turnover marker after spinal cord injury: A scoping review of human and animal studies.The journal of spinal cord medicine · 2023Article
- A multimodality intervention to improve musculoskeletal health, function, metabolism, and well-being in spinal cord injury: study protocol for the FIT-SCI randomized controlled trial.BMC musculoskeletal disorders · 2022Article
- Neurogenic Obesity and Skeletal Pathology in Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2021Review
- Lifestyle modifications and pharmacological approaches to improve sexual function and satisfaction in men with spinal cord injury: a narrative review.Spinal cord · 2020Review
- Prevention and management of osteoporosis and osteoporotic fractures in persons with a spinal cord injury or disorder: A systematic scoping review.The journal of spinal cord medicine · 2019Article
- Effects of leptin on femoral fracture in rats.Journal of biomedical research · 2018Article
- Effectiveness of two vitamin DSpinal cord series and cases · 2018Article
- Testosterone Plus Finasteride Prevents Bone Loss without Prostate Growth in a Rodent Spinal Cord Injury Model.Journal of neurotrauma · 2017Article
- Daily parathyroid hormone administration enhances bone turnover and preserves bone structure after severe immobilization-induced bone loss.Physiological reports · 2017Article
- Vitamin D and spinal cord injury: should we care?Spinal cord · 2016Review
- Are low levels of 25(OH) vitamin D and testosterone clinically relevant in men with paraplegia?The journal of spinal cord medicine · 2016Article
- Association between 25(OH)-vitamin D and testosterone levels: Evidence from men with chronic spinal cord injury.The journal of spinal cord medicine · 2016Article
- Serum leptin, bone mineral density and the healing of long bone fractures in men with spinal cord injury.Bosnian journal of basic medical sciences · 2015Article
- Sclerostin inhibition prevents spinal cord injury-induced cancellous bone loss.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
Corrections and comments
- Commented on by
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- Erratum issuedCorrigenda.2015
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextBone loss is a constant finding in patients with spinal cord injury (SCI).
objectiveWe sought to evaluate potential modifiable factors that could lead to bone loss in complete motor paraplegia by examining gonadal axis hormones, vitamin D status, and bone markers.
designThis is a cross sectional.
settingIt includes SCI Outpatient. PATIENTS AND OTHER
participantsTwenty-nine chronic male patients with SCI were compared with 17 age-matched, able-bodied men.
main outcome measureThe bone mineral density (BMD) of lower limbs and lumbar spine were measured using dual x-ray absorptiometry. Parathormone, 25-hydroxyvitamin D [25(OH)D], collagen type I C-terminal telopeptide (CTX), and sexual hormone were measured.
resultsPatients with SCI had lower BMD at the inferior limbs sites. CTX showed an inverse relationship with the time since injury. Patients had lower free T levels (SCI, 12.00 ± 2.91 vs controls, 19.51 ± 5.72; P ≤ .001), and the majority (72%) had normal/low levels of gonadotropins. Low T, however, was not related to low bone mass in patients with SCI. In the controls, the 25(OH)D level was positively correlated with the T and with the lumbar spine BMD, but these correlations were not observed in the SCI.
conclusionsImpairment of testicular function after SCI was indicated by the low levels of T and the loss of correlation between T and 25(OH)D levels; this correlation was present in the able-bodied controls. Inappropriate levels of gonadotropins were identified in most patients, featuring a hypogonadotropic hypogonadism and suggesting a disruption of the pituitary-gonadal axis. T concentrations might not be an effective target for bone loss therapy.
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