ArticlePloS one2014
Effect of different breathing aids on ventilation distribution in adults with cystic fibrosis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02721498 (Improving Outcome Measures For Physiotherapy Trials of Airway Clearance in Adults With Cystic Fibrosis), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Outcome Measures For Physiotherapy Trials of Airway Clearance in Adults With Cystic Fibrosis
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis.The Cochrane database of systematic reviews · 2019Pooled it
- Lung Volume Change Under Apnoeic Oxygenation With Different Flow Rates in Children: A Single-Centre Prospective Randomized Controlled Non-Inferiority Trial.Paediatric anaesthesia · 2026Trial
- Efficacy of a lung recruitment manoeuvre in children undergoing general anaesthesia with a supraglottic airway.British journal of anaesthesia · 2025Trial
- Trial
- Recommendations for lung ventilation and perfusion assessment with chest electrical impedance tomography in critically ill adult patients: an international evidence-based and expert Delphi consensus study.EClinicalMedicine · 2025Article
- Atelectasis in obese patients undergoing laparoscopic bariatric surgery are not increased upon discharge from Post Anesthesia Care Unit.Frontiers in medicine · 2023Article
- Changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: an observational study.Scientific reports · 2022Observational
- A narrative review of electrical impedance tomography in lung diseases with flow limitation and hyperinflation: methodologies and applications.Annals of translational medicine · 2020Review
- Investigating outcome measures for assessing airway clearance techniques in adults with cystic fibrosis: protocol of a single-centre randomised controlled crossover trial.BMJ open respiratory research · 2020Article
- Article
- A Review of Electrical Impedance Tomography in Lung Applications: Theory and Algorithms for Absolute Images.Annual reviews in control · 2019Article
- Estimating regions of air trapping from electrical impedance tomography data.Physiological measurement · 2018Article
- Evaluation of surrogate measures of pulmonary function derived from electrical impedance tomography data in children with cystic fibrosis.Physiological measurement · 2018Article
- Electrical impedance tomography.Annals of translational medicine · 2018Review
- Benefit of educational feedback for the use of positive expiratory pressure device.Brazilian journal of physical therapyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesWe investigated the effect of different breathing aids on ventilation distribution in healthy adults and subjects with cystic fibrosis (CF).
methodsIn 11 healthy adults and 9 adults with CF electrical impedance tomography measurements were performed during spontaneous breathing, continuous positive airway pressure (CPAP) and positive expiratory pressure (PEP) therapy randomly applied in upright and lateral position. Spatial and temporal ventilation distribution was assessed.
resultsThe proportion of ventilation directed to the dependent lung significantly increased in lateral position compared to upright in healthy and CF. This effect was enhanced with CPAP but neutralised with PEP, whereas the effect of PEP was larger in the healthy group. Temporal ventilation distribution showed exactly the opposite with homogenisation during CPAP and increased inhomogeneity with PEP.
conclusionsPEP shows distinct differences to CPAP with respect to its impact on ventilation distribution in healthy adults and CF subjects EIT might be used to individualise respiratory physiotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.