Trial reportAnnals of internal medicine2014
Quality-of-life outcomes with coronary artery bypass graft surgery in ischemic left ventricular dysfunction: a randomized trial.
Trial report in Annals of internal medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00023595 (Surgical Treatment for Ischemic Heart Failure), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Surgical Treatment for Ischemic Heart Failure (STICH)
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Effect of coronary artery bypass grafting on quality of life: a meta-analysis of randomized trials.European heart journal. Quality of care & clinical outcomes · 2022Pooled it
- Phenomapping the Response of Patients With Ischemic Cardiomyopathy With Reduced Ejection Fraction to Surgical Revascularization.Clinical cardiology · 2025Trial
- Cost-Effectiveness of Coronary Artery Bypass Surgery Versus Medicine in Ischemic Cardiomyopathy: The STICH Randomized Clinical Trial.Circulation · 2022Trial
- Enhancing early functional independence following cardiac surgery: a quality improvement programme.BMJ open quality · 2023Article
- The Effectiveness of Coronary Artery Bypass Grafting in Patients with Left Ventricular Dysfunction.Brazilian journal of cardiovascular surgery · 2023Article
- Revascularisation for Ischaemic Cardiomyopathy.Interventional cardiology (London, England) · 2023Review
- Myocardial Viability Testing in the Management of Ischemic Heart Failure.Life (Basel, Switzerland) · 2022Review
- Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts: Quality of Life (ROMA:QOL) - Rationale and Study Protocol.European heart journal. Quality of care & clinical outcomes · 2022Article
- Trends in Characteristics and Outcomes of Hospitalized Young Patients Undergoing Coronary Artery Bypass Grafting in the United States, 2004 to 2018.Journal of the American Heart Association · 2021Article
- Exercise tolerance and quality of life in patients with known or suspected coronary artery disease.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Article
- Effect of Acupressure on Pain Severity in Patients Undergoing Coronary Artery Graft: A Randomized Controlled Trial.Anesthesiology and pain medicine · 2018Article
- The Effect of Classic Chest Physiotherapy on Postoperative Pain Scores and Hospital Stay in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial.Galen medical journal · 2018Article
- Comparing the effectiveness of revascularization interventions with medical therapy in patients with ischemic cardiomyopathy: A systematic review and meta-analysis.Medical journal of the Islamic Republic of Iran · 2018Article
- Underutilization of Coronary Artery Disease Testing Among Patients Hospitalized With New-Onset Heart Failure.Journal of the American College of Cardiology · 2016Article
- Assessing quality-of-life outcomes in cardiovascular clinical research.Nature reviews. Cardiology · 2016Review
- Managing Heart Failure Patients with Multivessel Disease - Coronary Artery Bypass Graft versus Percutaneous Coronary Intervention.Cardiac failure review · 2015Article
- Patient-reported outcomes in heart failure: existing measures and future uses.Current heart failure reports · 2015Review
- [Effectiveness of tertiary prevention on quality of life and control of risk factors in patients with ischemic coronary heart disease].Archivos peruanos de cardiologia y cirugia cardiovascularArticle
- Article
Corrections and comments
- SummaryForPatientsIn
Authors and funding
17 authors at 10 institutions in 4 countries.
Funding
Abstract
backgroundThe STICH (Surgical Treatment for Ischemic Heart Failure) trial compared a strategy of routine coronary artery bypass grafting (CABG) with guideline-based medical therapy for patients with ischemic left ventricular dysfunction.
objectiveTo describe treatment-related quality-of-life (QOL) outcomes, a major prespecified secondary end point in the STICH trial.
designRandomized trial. (ClinicalTrials.gov: NCT00023595).
setting99 clinical sites in 22 countries. PATIENTS: 1212 patients with a left ventricular ejection fraction of 0.35 or less and coronary artery disease.
interventionRandom assignment to medical therapy alone (602 patients) or medical therapy plus CABG (610 patients). MEASUREMENTS: A battery of QOL instruments at baseline (98.9% complete) and 4, 12, 24, and 36 months after randomization (collection rates were 80% to 89% of those eligible). The principal prespecified QOL measure was the Kansas City Cardiomyopathy Questionnaire, which assesses the effect of heart failure on patients' symptoms, physical function, social limitations, and QOL.
resultsThe Kansas City Cardiomyopathy Questionnaire overall summary score was consistently higher (more favorable) in the CABG group than in the medical therapy group by 4.4 points (95% CI, 1.8 to 7.0 points) at 4 months, 5.8 points (CI, 3.1 to 8.6 points) at 12 months, 4.1 points (CI, 1.2 to 7.1 points) at 24 months, and 3.2 points (CI, 0.2 to 6.3 points) at 36 months. Sensitivity analyses to account for the effect of mortality on follow-up QOL measurement were consistent with the primary findings. LIMITATION: Therapy was not masked.
conclusionIn this cohort of symptomatic high-risk patients with ischemic left ventricular dysfunction and multivessel coronary artery disease, CABG plus medical therapy produced clinically important improvements in quality of life compared with medical therapy alone over 36 months. PRIMARY FUNDING SOURCE: National Heart, Lung, and Blood Institute.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.