Evidence map›Paper›PMID 25222274›Full record

ArticlePloS one2014

Feeding a high-concentrate corn straw diet induced epigenetic alterations in the mammary tissue of dairy cows.

Guozhong Dong, Min Qiu, Changjin Ao, Jun Zhou, Khas-Erdene, Xi Wang, Zhu Zhang, You Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. How Does Nutrition Affect the Epigenetic Changes in Dairy Cows?Animals : an open access journal from MDPI · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. DNA methylation studies in cattle.Journal of applied genetics · 2021
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Guozhong DongCollege of Animal Science and Technology, and Key Laboratory of Grass and Herbivores of Chongqing, Southwest University, Beibei, Chongqing, China.
Min QiuCollege of Animal Science and Technology, and Key Laboratory of Grass and Herbivores of Chongqing, Southwest University, Beibei, Chongqing, China.
Changjin AoCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
Jun ZhouCollege of Animal Science and Technology, and Key Laboratory of Grass and Herbivores of Chongqing, Southwest University, Beibei, Chongqing, China.
Khas-ErdeneCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
Xi WangCollege of Animal Science and Technology, and Key Laboratory of Grass and Herbivores of Chongqing, Southwest University, Beibei, Chongqing, China.
Zhu ZhangCollege of Animal Science and Technology, and Key Laboratory of Grass and Herbivores of Chongqing, Southwest University, Beibei, Chongqing, China.
You YangCollege of Animal Science and Technology, and Key Laboratory of Grass and Herbivores of Chongqing, Southwest University, Beibei, Chongqing, China.
Southwest University · CNInner Mongolia Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe objective of this study was to investigate the effects of feeding a high-concentrate corn straw (HCS) diet (65% concentrate+35% corn straw) on the epigenetic changes in the mammary tissue of dairy cows in comparison with a low-concentrate corn straw (LCS) diet (46% concentrate+54% corn straw) and with a low-concentrate mixed forage (LMF) diet (46% concentrate+54% mixed forage). EXPERIMENTAL

designMultiparous mid-lactation Chinese Holstein cows were fed one of these three diets for 6 weeks, at which time blood samples and mammary tissue samples were collected. Mammary arterial and venous blood samples were analyzed for lipopolysaccharide (LPS) concentrations while mammary tissue samples were assayed for histone H3 acetylation and the methylation of specific genes associated with fat and protein synthesis.

resultsExtraction of histones and quantification of histone H3 acetylation revealed that acetylation was significantly reduced in cows fed the HCS diet, as compared with cows fed the LCS diet. Cows fed the HCS diet had significantly higher LPS concentrations in the mammary arterial blood, as compared with cows fed the LCS diet. We found that the extent of histone H3 acetylation was negatively correlated with LPS concentrations. The methylation of the stearoyl-coenzyme A desaturase gene associated with milk fat synthesis was increased in cows fed the HCS diet. By contrast, methylation of the gene encoding the signal transducer and activator of transcription 5A was reduced in cows fed the HCS diet, suggesting that feeding a high-concentrate corn straw diet may alter the methylation of specific genes involved in fat and protein synthesis in the mammary tissue of dairy cows.

conclusionsFeeding the high-concentrate diet induced epigenetic changes in the mammary tissues of dairy cows, possibly through effecting the release of differing amounts of LPS into the mammary blood.

Indexed as

AcetylationAnimal FeedAnimalsCattleDairyingEpigenesis, GeneticFemaleHistonesLipopolysaccharidesMammary Glands, AnimalZea maysHistonesLipopolysaccharides

Identifiers

PMID25222274
PMCPMC4164636
OpenAlexW2091339551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.