ArticlePloS one2014
Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Visceral adiposity, metabolic health and aging.Nature aging · 2026Review
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- Eubacterium siraeum suppresses fat deposition via decreasing the tyrosine-mediated PI3K/AKT signaling pathway in high-fat diet-induced obesity.Microbiome · 2024Article
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- Maternal PBDE exposure disrupts gut microbiome and promotes hepatic proinflammatory signaling in humanized PXR-transgenic mouse offspring over time.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
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- Effect of safflower oil (Food chemistry. Molecular sciences · 2022Article
- Dietary Oxidized Linoleic Acids Modulate Fatty Acids in Mice.Journal of lipid and atherosclerosis · 2022Article
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- Dietary Fat and Cancer-Which Is Good, Which Is Bad, and the Body of Evidence.International journal of molecular sciences · 2020Review
- Metabolite profile comparisons between ascending and descending colon tissue in healthy adults.World journal of gastroenterology · 2020Article
- Potential Nutritional and Metabolomic Advantages of High Fat Oral Supplementation in Pancreatectomized Pancreaticobiliary Cancer Patients.Nutrients · 2019Article
- Bioactivity and modulatory functions ofToxicology reports · 2019Article
- Resveratrol Modulates Desaturase Expression and Fatty Acid Composition of Cultured Hepatocytes.Frontiers in nutrition · 2018Article
- Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats.Scientific reports · 2017Article
- Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats.Scientific reports · 2017Article
- The role of sex and body weight on the metabolic effects of high-fat diet in C57BL/6N mice.Nutrition & diabetes · 2017Article
- Improvement of Liver Cell Therapy in Rats by Dietary Stearic Acid.Iranian biomedical journal · 2016Article
- Ameliorative effects ofAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Stearic acid (C18:0) is a long chain dietary saturated fatty acid that has been shown to reduce metastatic tumor burden. Based on preliminary observations and the growing evidence that visceral fat is related to metastasis and decreased survival, we hypothesized that dietary stearic acid may reduce visceral fat. Athymic nude mice, which are used in models of human breast cancer metastasis, were fed a stearic acid, linoleic acid (safflower oil), or oleic acid (corn oil) enriched diet or a low fat diet ad libitum. Total body weight did not differ significantly between dietary groups over the course of the experiment. However visceral fat was reduced by ∼70% in the stearic acid fed group compared to other diets. In contrast total body fat was only slightly reduced in the stearic acid diet fed mice when measured by dual-energy x-ray absorptiometry and quantitative magnetic resonance. Lean body mass was increased in the stearic acid fed group compared to all other groups by dual-energy x-ray absorptiometry. Dietary stearic acid significantly reduced serum glucose compared to all other diets and increased monocyte chemotactic protein-1 (MCP-1) compared to the low fat control. The low fat control diet had increased serum leptin compared to all other diets. To investigate possible mechanisms whereby stearic acid reduced visceral fat we used 3T3L1 fibroblasts/preadipocytes. Stearic acid had no direct effects on the process of differentiation or on the viability of mature adipocytes. However, unlike oleic acid and linoleic acid, stearic acid caused increased apoptosis (programmed cell death) and cytotoxicity in preadipocytes. The apoptosis was, at least in part, due to increased caspase-3 activity and was associated with decreased cellular inhibitor of apoptosis protein-2 (cIAP2) and increased Bax gene expression. In conclusion, dietary stearic acid leads to dramatically reduced visceral fat likely by causing the apoptosis of preadipocytes.
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