ArticlePloS one2014
Interleukin-1β-31C/T and -511T/C polymorphisms were associated with preeclampsia in Chinese Han population.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- A Study ofBioMed research international · 2017Trial
- Article
- Predictive model based on gene and laboratory data for intravenous immunoglobulin resistance in Kawasaki disease in a Chinese population.Pediatric rheumatology online journal · 2021Article
- Genetic markers for preeclampsia in Peruvian women.Colombia medica (Cali, Colombia) · 2021Article
- Relationship between common interleukin 1-beta gene polymorphisms and the risk of gestational disorders: An updated meta-analysis.Medical journal of the Islamic Republic of Iran · 2021Review
- Association of VEGFA and IL1β gene polymorphisms with preeclampsia in Sudanese women.Molecular genetics & genomic medicine · 2020Article
- Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia.Journal of immunology research · 2020Article
- Candidate SNP markers of reproductive potential are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters.BMC genomics · 2018Article
- Polymorphisms of the IL27 gene in a Chinese Han population complicated with pre-eclampsia.Scientific reports · 2016Article
- Contribution of TIMP3 polymorphisms to the development of preeclampsia in Han Chinese women.Journal of assisted reproduction and genetics · 2015Article
- Role of IL-17 Variants in Preeclampsia in Chinese Han Women.PloS one · 2015Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of our study is to investigate the relationship between IL-1β -31C/T (rs1143627) and -511T/C (rs16944) polymorphisms and the preeclampsia (PE), and analyze the Linkage disequilibrium (LD) and haplotype frequency of the two polymorphism loci.
methodsPolymorphisms at -31C/T and -511T/C of IL-1β were genotyped with the method of polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP) in 232 PE and 447 control subjects. Genotype and allele frequencies between case-control groups were compared by chi-square(X2) tests. Two-point LD and haplotype frequency analyses were done with the software Haploview4.2.
resultsSignificant statistical differences were found between PE and control groups regarding genotype and allele frequencies of the two polymorphisms of IL-1β (For IL-1β -31C/T: X2 = 11.478, P = 0.003; For IL-1β-511T/C: X2 = 9.687, P = 0.008). LD analysis revealed that the IL-1β -31C/T SNP was in high LD with the IL-1β-511C/T SNP(D' = 0.92, r2 = 0.79). Both CT and TC haplotypes showed significant differences between case and control groups. Only the plasma level of Prothrombin Time had a significantly statistical difference among TT, CT and CC groups of the preeclamptic two polymorphisms of IL-1β-31C/T and -511T/C (for IL-1β-31C/T, F = 1.644, P = 0.01; F = 1.587, P = 0.016).
conclusionOur results revealed IL-1β was associated with the PE in Chinese Han population. The CT haplotype may increase the risk of PE, while haplotype TC could be considered as a protective haplotype of PE.
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