ReviewMolecules (Basel, Switzerland)2014
Native chemical ligation: a boon to peptide chemistry.
Review in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- AMCL: supervised contrastive learning with hard sample mining for multi-functional therapeutic peptide prediction.BMC biology · 2025Article
- Review on the o-Aminoaniline Moiety in Peptide and Protein Chemistry.Chembiochem : a European journal of chemical biology · 2025Review
- Assembly of Biologically Functional Structures by Nucleic Acid Templating: Implementation of a Strategy to Overcome Inhibition by Template Excess.Molecules (Basel, Switzerland) · 2022Article
- Synthesis of the extracellular domain of GLP-1R by chemical and biotechnological approaches.RSC advances · 2022Article
- Utilizing a Baculovirus/Insect Cell Expression System and Expressed Protein Ligation (EPL) for Protein Semisynthesis.Current protocols · 2022Article
- Small and Simple, yet Sturdy: Conformationally Constrained Peptides with Remarkable Properties.International journal of molecular sciences · 2021Review
- Methodologies for Backbone Macrocyclic Peptide Synthesis Compatible With Screening Technologies.Frontiers in chemistry · 2020Review
- Structure-Function Elucidation of a New α-Conotoxin, MilIA, fromMarine drugs · 2019Article
- Peptide-Based Functional Biomaterials for Soft-Tissue Repair.Frontiers in bioengineering and biotechnology · 2019Review
- Structure and Synthesis of Antifungal Disulfide β-Strand Proteins from Filamentous Fungi.Microorganisms · 2018Review
- Application of dehydroalanine as a building block for the synthesis of selenocysteine-containing peptides.RSC advances · 2018Article
- Synthetic Evaluation of Standard and Microwave-Assisted Solid Phase Peptide Synthesis of a Long Chimeric Peptide Derived from FourMolecules (Basel, Switzerland) · 2018Article
- Chemical synthesis of membrane proteins: a model study on the influenza virus B proton channel.Chemical science · 2018Article
- Recent Progress in the Chemical Synthesis of Class II and S-Glycosylated Bacteriocins.Frontiers in microbiology · 2018Review
- Controlled Self-assembly of Stem Cell Aggregates Instructs Pluripotency and Lineage Bias.Scientific reports · 2017Article
- Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II.Cell reports · 2017Article
- Tumor-targeting peptides from combinatorial libraries.Advanced drug delivery reviews · 2017Review
- The Amadori Rearrangement for Carbohydrate Conjugation: Scope and Limitations.European journal of organic chemistry · 2016Article
- Surface functionalization and dynamics of polymeric cell culture substrates.Current opinion in biotechnology · 2016Review
- Peptide Conjugation to a Polymer Coating via Native Chemical Ligation of Azlactones for Cell Culture.Biomacromolecules · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of chemical ligation within the realm of peptide chemistry has opened various opportunities to expand the applications of peptides/proteins in biological sciences. Expansion and refinement of ligation chemistry has made it possible for the entry of peptides into the world of viable oral therapeutic drugs through peptide backbone cyclization. This progression has been a journey of chemical exploration and transition, leading to the dominance of native chemical ligation in the present advances of peptide/protein applications. Here we illustrate and explore the historical and current nature of peptide ligation, providing a clear indication to the possibilities and use of these novel methods to take peptides outside their typically defined boundaries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.