Evidence map›Paper›PMID 25221786›Full record

ArticleAdvances in otolaryngology2014

Evaluation of Autogenous Engineered Septal Cartilage Grafts in Rabbits- A Minimally Invasive Preclinical Model.

Anton Kushnaryov, Tomonoro Yamaguchi, Kristen K Briggs, Van W Wong, Marsha Reuther, Monica Neuman, Victor Lin, Robert L Sah, Koichi Masuda, Deborah Watson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in otolaryngology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Anton KushnaryovDivision of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla, California, USA ; Head and Neck Surgery Section, VA San Diego Healthcare System, San Diego, California, USA.
Tomonoro YamaguchiDepartment of Orthopedic Surgery, University of California, San Diego, La Jolla, California, USA.
Kristen K BriggsDepartment of Bioengineering, University of California, San Diego, La Jolla, California, USA.
Van W WongDepartment of Bioengineering, University of California, San Diego, La Jolla, California, USA.
Marsha ReutherDivision of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla, California, USA ; Head and Neck Surgery Section, VA San Diego Healthcare System, San Diego, California, USA.
Monica NeumanCreighton University School of Medicine, Omaha, Nebraska, USA.
Victor LinUniversity of North Texas Health Sciences Center, Fort Worth, Texas, USA.
Robert L SahDepartment of Bioengineering, University of California, San Diego, La Jolla, California, USA.
Koichi MasudaDepartment of Orthopedic Surgery, University of California, San Diego, La Jolla, California, USA.
Deborah WatsonDivision of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla, California, USA ; Head and Neck Surgery Section, VA San Diego Healthcare System, San Diego, California, USA.
University of California San Diego · USCreighton University · USUniversity of North Texas · US

Funding

TISSUE ACQUISITION, MORPHOLOGY, AND CELL CULTUREP01AG007996 · NIA · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI SAH, ROBERT L · 1989 to 2016
$26.0M
Developing Articular Cartilage: Function &RemodelingR01AR044058 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAH, ROBERT L · 2000 to 2010
$3.3M
UCSD Medical Student Summer Aging Research TrainingT35AG026757 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Benjamin Hyun Han, Ellen Eun-Ok Lee · 2005 to 2026
$2.2M
NIAMS NIH HHS R01 AR044058NIA NIH HHS P01 AG007996NIA NIH HHS T35 AG026757
6 · The paper itself

Abstract

objectivesEvaluate safety of autogenous engineered septal neocartilage grafts.Compare properties of implanted grafts versus STUDY

designProspective, basic science.

settingResearch laboratory.

methodsConstructs were fabricated from septal cartilage and serum harvested from adult rabbits and then cultured

resultsNo systemic or serious local complications were observed. After 30 and 60 days, implanted constructs contained more DNA (p<0.01) and less sGAG per DNA (p<0.05) when compared with

conclusionAutogenous engineered septal cartilage grafts were well tolerated. As seen in experiments with athymic mice, implanted constructs accumulated more DNA and less sGAG when compared with

Indexed as

animal modelautologous graftcartilage tissue engineeringhuman septal cartilageNew Zealand White rabbit

Identifiers

PMID25221786
PMCPMC4159164
OpenAlexW2106996378

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.