ArticleAdvanced biomedical research2014
A comparison of surfactant administration through i-gel and ET-tube in the treatment of respiratory distress syndrome in newborns weighing more than 2000 grams.
Article in Advanced biomedical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants with or at risk of respiratory distress syndrome.The Cochrane database of systematic reviews · 2024Pooled it
- Comparison of laryngeal mask airway and endotracheal tube placement in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2024Trial
- Pulmonary comorbidities and response to surfactant in late preterm infants: a multicenter cohort study.Pediatric research · 2026Observational
- Article
- Feasibility and safety of surfactant administration via laryngeal mask airway as first-line therapy for a select newborn population: results of a standardized clinical protocol.Journal of perinatology : official journal of the California Perinatal Association · 2025Observational
- Laryngeal Mask for Minimally-invasive Surfactant Administration: A Narrative Review.Current pediatric reviews · 2025Review
- Less Invasive Surfactant Administration: A Viewpoint.American journal of perinatology · 2024Review
- Clinical decision thresholds for surfactant administration in preterm infants: a systematic review and network meta-analysis.EClinicalMedicine · 2023Article
- Implementation of Surfactant Administration through Laryngeal or Supraglottic Airways (SALSA): A Jordanian NICU's Journey to Improve Surfactant Administration.Children (Basel, Switzerland) · 2022Article
- Laryngeal Masks in Neonatal Resuscitation-A Narrative Review of Updates 2022.Children (Basel, Switzerland) · 2022Review
- Non-invasive administration of poractant-α in neonatal respiratory distress syndrome via a supraglottic device in the clinical practice in a second level neonatal unit: comparison of LMA® vs iGel® devices.Acta bio-medica : Atenei Parmensis · 2022Article
- Surfactant Administration Through Laryngeal or Supraglottic Airways (SALSA): A Viable Method for Low-Income and Middle-Income Countries.Frontiers in pediatrics · 2022Review
- Lung Deposition of Surfactant Delivered via a Dedicated Laryngeal Mask Airway in Piglets.Pharmaceutics · 2021Article
- Alternative Methods of Surfactant Administration in Preterm Infants with Respiratory Distress Syndrome: State of the Art.Turkish archives of pediatrics · 2021Article
- Guidelines for surfactant replacement therapy in neonates.Paediatrics & child health · 2021Review
- Update of minimally invasive surfactant therapy.Korean journal of pediatrics · 2017Review
- Surfactant for Respiratory Distress Syndrome: New Ideas on a Familiar Drug with Innovative Applications.Neonatology · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurfactant administration together with nasal Continuous Positive Airway Pressure (nCPAP) administration is considered to be the basis for Newborn's Respiratory Distress Syndrome (RDS) management. This study evaluated the method of directing the surfactant to the lungs in newborns affiliated with RDS through i-gel (i-gel surfactant administration/i-gelSA) compared to the standard care INSURE method, in a clinical trial. MATERIALS AND
methodsThis randomized control trial (RCT) was done on newborns weighing ≥2000 g, with RDS, while being supported with Bubble-CPAP. Newborns, which required FiO2 ≥0.3 under Continuous Distending Pressure (CDP) ≥5 cm H2O for more than 30 minutes to maintain SpO2 in the range of 89 - 95%, were given 100 mg/kg of Survanta. In the interventional group or the i-gelSA (i-gel Surfactant Administration) group, 35 newborns experienced surfactant administration with i-gel and 35 newborns in the control or INSURE group. The average a/APO2 before and after surfactant administration, repeated need for surfactant administration, average nCPAP duration, need for invasive mechanical ventilation, pneumothorax, and the average duration of hospitalization in the Neonatal Intensive Care Unit (NICU) were compared.
resultsAlthough the average a/APO2 showed no significant difference before the procedure; in the i-gelSA group, this average was meaningfully higher after the administration of the surfactant (P = 0.001). The other factors showed no significant difference.
conclusionAccording to the results of this study, the surfactant administration using i-gel was more successful in oxygenation improvement than the INSURE method, and the i-gel method could even be promoted to the standard care position. However, more research is needed in this area.
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