ArticleFrontiers in aging neuroscience2014
Microstructure, length, and connection of limbic tracts in normal human brain development.
Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 38 citations in OpenAlex.
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- Diffusion properties of the fornix assessed by deterministic tractography shows age, sex, volume, cognitive, hemispheric, and twin relationships in young adults from the Human Connectome Project.Brain structure & function · 2021Article
- Acute pediatric traumatic brain injury severity predicts long-term verbal memory performance through suppression by white matter integrity on diffusion tensor imaging.Brain imaging and behavior · 2020Article
- Differential White Matter Maturation from Birth to 8 Years of Age.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Fornix Integrity Is Differently Associated With Cognition in Healthy Aging and Non-amnestic Mild Cognitive Impairment: A Pilot Diffusion Tensor Imaging Study in Thai Older Adults.Frontiers in aging neuroscience · 2020Article
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- Delineation of early brain development from fetuses to infants with diffusion MRI and beyond.NeuroImage · 2019Review
- Graph theory analysis of DTI tractography in children with traumatic injury.NeuroImage. Clinical · 2019Article
- Diffusion MRI of white matter microstructure development in childhood and adolescence: Methods, challenges and progress.Developmental cognitive neuroscience · 2018Review
- Article
- Short-range connections in the developmental connectome during typical and atypical brain maturation.Neuroscience and biobehavioral reviews · 2017Review
- Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging.Behavioural brain research · 2017Article
- Commentary: Microstructure, length, and connection of limbic tracts in normal human brain development.Frontiers in neuroscience · 2017Article
- Longitudinal diffusion tensor imaging after pediatric traumatic brain injury: Impact of age at injury and time since injury on pathway integrity.Human brain mapping · 2016Article
- Large-Scale Hypoconnectivity Between Resting-State Functional Networks in Unmedicated Adolescent Major Depressive Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Characterization of ten white matter tracts in a representative sample of Cuban population.BMC medical imaging · 2016Article
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9 authors at 6 institutions in 2 countries.
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Abstract
The cingulum and fornix play an important role in memory, attention, spatial orientation, and feeling functions. Both microstructure and length of these limbic tracts can be affected by mental disorders such as Alzheimer's disease, depression, autism, anxiety, and schizophrenia. To date, there has been little systematic characterization of their microstructure, length, and functional connectivity in normally developing brains. In this study, diffusion tensor imaging (DTI) and resting state functional MRI (rs-fMRI) data from 65 normally developing right-handed subjects from birth to young adulthood was acquired. After cingulate gyrus part of the cingulum (cgc), hippocampal part of the cingulum (cgh) and fornix (fx) were traced with DTI tractography, absolute and normalized tract lengths and DTI-derived metrics including fractional anisotropy, mean, axial, and radial diffusivity were measured for traced limbic tracts. Free water elimination (FWE) algorithm was adopted to improve accuracy of the measurements of DTI-derived metrics. The role of these limbic tracts in the functional network at birth and adulthood was explored. We found a logarithmic age-dependent trajectory for FWE-corrected DTI metric changes with fast increase of microstructural integrity from birth to 2 years old followed by a slow increase to 25 years old. Normalized tract length of cgc increases with age, while no significant relationship with age was found for normalized tract lengths of cgh and fx. Stronger microstructural integrity on the left side compared to that of the right side was found. With integrated DTI and rs-fMRI, the key connectional role of cgc and cgh in the default mode network was confirmed as early as birth. Systematic characterization of length and DTI metrics after FWE correction of limbic tracts offers insight into their morphological and microstructural developmental trajectories. These trajectories may serve as a normal reference for pediatric patients with mental disorders.
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