ArticleNanoscale research letters2014
pH-responsive drug delivery system based on hollow silicon dioxide micropillars coated with polyelectrolyte multilayers.
Article in Nanoscale research letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Composite polymer/wax coatings as a corrosion barrier of bioresorbable magnesium coronary stents.Heliyon · 2024Article
- Real-Time Monitoring of Doxorubicin Release from Hybrid Nanoporous Anodic Alumina Structures.Sensors (Basel, Switzerland) · 2021Article
- Optical Platform to Analyze a Model Drug-Loading and Releasing Profile Based on Nanoporous Anodic Alumina Gradient Index Filters.Nanomaterials (Basel, Switzerland) · 2021Article
- Synthesis and characterization of magnetic nanoparticles coated with polystyrene sulfonic acid for biomedical applications.Science and technology of advanced materials · 2020Article
- pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles.ACS omega · 2020Article
- Enhancement of Peroxidase Stability Against Oxidative Self-Inactivation by Co-immobilization with a Redox-Active Protein in Mesoporous Silicon and Silica Microparticles.Nanoscale research letters · 2016Article
- Sustained, Controlled and Stimuli-Responsive Drug Release Systems Based on Nanoporous Anodic Alumina with Layer-by-Layer Polyelectrolyte.Nanoscale research letters · 2016Article
- pH Responsiveness of Multilayered Films and Membranes Made of Polysaccharides.Langmuir : the ACS journal of surfaces and colloids · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report on the fabrication of polyelectrolyte multilayer-coated hollow silicon dioxide micropillars as pH-responsive drug delivery systems. Silicon dioxide micropillars are based on macroporous silicon formed by electrochemical etching. Due to their hollow core capable of being loaded with chemically active agents, silicon dioxide micropillars provide additional function such as drug delivery system. The polyelectrolyte multilayer was assembled by the layer-by-layer technique based on the alternative deposition of cationic and anionic polyelectrolytes. The polyelectrolyte pair poly(allylamine hydrochloride) and sodium poly(styrene sulfonate) exhibited pH-responsive properties for the loading and release of a positively charged drug doxorubicin. The drug release rate was observed to be higher at pH 5.2 compared to that at pH 7.4. Furthermore, we assessed the effect of the number of polyelectrolyte bilayers on the drug release loading and release rate. Thus, this hybrid composite could be potentially applicable as a pH-controlled system for localized drug release.
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Registered trials
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