Evidence map›Paper›PMID 25221429›Full record

ArticleLipid insights2014

Lipid Droplets as Signaling Platforms Linking Metabolic and Cellular Functions.

Estela L Arrese, Fredy Z Saudale, Jose L Soulages

Abstract read
In one paragraph

Article in Lipid insights, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Lipid Metabolism in Diapause.Advances in experimental medicine and biology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Vascular ATGL-dependent lipolysis and the activation of cPLACellular and molecular life sciences : CMLS · 2024
    Article
  9. Etiology of lipid-laden macrophages in the lung.International immunopharmacology · 2023
    Review
  10. Article
  11. Article
  12. Adaptive and maladaptive roles of lipid droplets in health and disease.American journal of physiology. Cell physiology · 2022
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Lipid Droplets in Neurodegenerative Disorders.Frontiers in neuroscience · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Estela L ArreseDepartment of Biochemistry and Molecular Biology; Oklahoma State University; Stillwater, OK, 74078, USA.
Fredy Z SaudaleDepartment of Biochemistry and Molecular Biology; Oklahoma State University; Stillwater, OK, 74078, USA.
Jose L SoulagesDepartment of Biochemistry and Molecular Biology; Oklahoma State University; Stillwater, OK, 74078, USA.

Funding

Mobilization of Triacylglycerol Stores in InsectsR01GM064677 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI ARRESE, ESTELA L. · 2002 to 2018
$3.2M
NIGMS NIH HHS R01 GM064677
6 · The paper itself

Abstract

The main cells of the adipose tissue of animals, adipocytes, are characterized by the presence of large cytosolic lipid droplets (LDs), which store triglyceride (TG) and cholesterol. However, most cells have LDs and the ability to store lipids. LDs have a well-known central role in storage and provision of fatty acids and cholesterol. However, the complexity of the regulation of lipid metabolism on the surface of the LDs is still a matter of intense study. Beyond this role, a number of recent studies have suggested that LDs have major functions in other cellular processes, such as protein storage and degradation, and infection and immunity. Thus, our perception of LDs, from simple globules of fat to highly dynamic organelles of unexpected complexity, has been radically transformed. Here we compiled some recent evidence supporting the emerging view that LDs act as platforms connecting a number of relevant metabolic and cellular functions.

Indexed as

fat bodyLipid dropletlipid metabolismlipoproteinperilipintriglycerides

Identifiers

PMID25221429
PMCPMC4161058

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.