ArticleMolecular vision2014
Keratoconus is associated with increased copy number of mitochondrial DNA.
Article in Molecular vision, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Deciphering mitochondrial dysfunction in keratoconus: Insights into ACSL4 from machine learning-based bulk and single-cell transcriptome analyses and experimental validation.Computational and structural biotechnology journal · 2025Article
- Gender-specific association ofFrontiers in genetics · 2024Article
- Association between Polymorphism rs61876744 inGenes · 2023Article
- Changes in Nuclear Gene Expression Related to Mitochondrial Function Affect Extracellular Matrix, Collagens, and Focal Adhesion in Keratoconus.Translational vision science & technology · 2021Article
- Genetic Aspects of Keratoconus: A Literature Review Exploring Potential Genetic Contributions and Possible Genetic Relationships with Comorbidities.Ophthalmology and therapy · 2018Review
- Polymorphism rs13334190 in zinc finger protein 469 (ZNF469) is not a risk factor for keratoconus in a Saudi cohort.BMC research notes · 2017Article
- Analysis of the VSX1 gene in sporadic keratoconus patients from China.BMC ophthalmology · 2017Article
- Inhibition of autophagy enhances the selective anti-cancer activity of tigecycline to overcome drug resistance in the treatment of chronic myeloid leukemia.Journal of experimental & clinical cancer research : CR · 2017Article
- Contact Lenses for Keratoconus- Current Practice.The open ophthalmology journal · 2017Article
- Keratoconus: an inflammatory disorder?Eye (London, England) · 2015Review
- Case-control association between CCT-associated variants and keratoconus in a Saudi Arabian population.Journal of negative results in biomedicine · 2015Article
- Screening of the Seed Region of MIR184 in Keratoconus Patients from Saudi Arabia.BioMed research international · 2015Article
- Nonrandom Distribution of miRNAs Genes and Single Nucleotide Variants in Keratoconus Loci.PloS one · 2015Article
- Genetics of keratoconus: where do we stand?Journal of ophthalmology · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the possible association of oxidative stress with keratoconus (KC), we estimated the changes in relative mitochondrial DNA (mtDNA) content.
methodsThe study included 119 patients with KC and 208 controls matched for gender, ethnicity, and systemic disease status. We selected controls who were older than the patients since the mtDNA copy number tends to increase with age. The age mean (standard deviation) was 26.4(7.6) and 54.5(14.4) years for the patients and controls, respectively. The relative mtDNA copy number was estimated with the real-time quantitative PCR (qPCR) method using ND1 as the mtDNA gene and human globulin (HGB; also known as the cytoglobin gene, CYGB) as the reference single-copy nuclear gene.
resultsThe mean relative mtDNA content was significantly higher in patients with KC (1.20±0.45) than in the normal control subjects (1.04±0.36; p = 0.0004). Subjects with high mtDNA content (>1.259, i.e., greater than 75(th) percentile) were at an increased risk of the disease (odds ratio = 2.62, 95% confidence interval = 1.40 to 4.89; p =0.0025).
conclusionsIncreased mtDNA content in patients with KC may indicate mitochondrial respiratory chain defects and thus mitochondrial-abnormality involvement.
Indexed as
Identifiers
25221426PMC4153421W2098685511What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.