ArticleAnnals of Indian Academy of Neurology2014
Major outcomes of patients with tuberculous meningitis on directly observed thrice a week regime.
Article in Annals of Indian Academy of Neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Treatment outcomes of tuberculous meningitis in adults: a systematic review and meta-analysis.BMC pulmonary medicine · 2019Pooled it
- Expression of autophagy-related genes in cerebrospinal fluid of patients with tuberculous meningitis.Experimental and therapeutic medicine · 2018Article
- Six months therapy for tuberculous meningitis.The Cochrane database of systematic reviews · 2016Review
- Tuberculous meningitis on directly observed thrice a week regime.Annals of Indian Academy of NeurologyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRevised National Tuberculosis Control Programme (RNTCP) of Government of India provides intermittent thrice-a-week directly observed treatment short course (RNTCP regimen).
objectiveAssessments of all-cause mortality and nine-month morbidity outcomes of patients with tuberculous meningitis (TBM) on RNTCP regimen. MATERIALS AND
methodsWe prospectively followed up patients registered with RNTCP center, with a diagnosis of TBM from January 1(st), 2010 to December 31(st), 2011. Morbidity was assessed using modified Rankin Scale (mRS).
resultsWe had 43 patients with median duration for follow-up of 396 days and that of survivors of 425 days. Two patients defaulted. Fourteen patients (32.5%) had mRS score of 4 to 6 and 29 had mRS of 0 to 3 after 9-month treatment. Severe disability was not related to any factor on logistic regression. Severe disability was seen in one patient (6.66%) among the 15 patients with stage 1, nine (37.5%) out of 24 patients with stage 2 and three (75%) out of 4 patients with stage 3 disease. Eight patients died (18.6%) of whom 4 died during the intensive phase and 4 during the continuation phase of RNTCP regimen. Mortality was independently related to treatment failure with adjusted Hazard ratio of 8.29 (CI: 1.38-49.78) (P = 0.02). One patient (6.66%) died out of the 15 patients with stage 1 disease, 5 (20.8%) out of 24 patients with stage 2 disease and 2 (50%) out of the 4 with stage 3 disease. DISCUSSION AND
conclusionRNTCP regimen was associated with good compliance, comparable mortality and morbidity.
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