ArticleZeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology2014
Fish is Fish: the use of experimental model species to reveal causes of skeletal diversity in evolution and disease.
Article in Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed.
- Functional validation using a zebrafish model reclassifies the rare COL1A2 p.Gly418Ala variant as a cause of Osteogenesis Imperfecta.Scientific reports · 2026Article
- Evaluating Toxicity and Anti-Osteogenic Activity of Artemisinin-Inspired Endoperoxides in Zebrafish Larvae.Toxics · 2026Article
- Paradise fish (Macropodus opercularis) as a complementary translational model for emotional and cognitive function.Communications biology · 2025Article
- Article
- Zebrafish as a Model for Osteoporosis: Functional Validations of Genome-Wide Association Studies.Current osteoporosis reports · 2023Review
- Skeletal Morphogenesis and Anomalies in Gilthead Seabream: A Comprehensive Review.International journal of molecular sciences · 2023Review
- Characterization of Fibrodysplasia Ossificans Progessiva relevant Acvr1/Acvr2 Activin receptors in medaka (Oryzias latipes).PloS one · 2023Article
- FELASA-AALAS Recommendations for Monitoring and Reporting of Laboratory Fish Diseases and Health Status, with an Emphasis on Zebrafish (Comparative medicine · 2022Article
- Zebrafish as a Vertebrate Model for Studying Nodavirus Infections.Frontiers in immunology · 2022Article
- Dynamics of the Zebrafish Skeleton in Three Dimensions During Juvenile and Adult Development.Frontiers in physiology · 2022Article
- A Baseline for Skeletal Investigations in Medaka (Frontiers in endocrinology · 2022Review
- Impacts of microplastics on immunity.Frontiers in toxicology · 2022Review
- Toxicity of silver nanoparticles on different tissues in adult Danio rerio.Fish physiology and biochemistry · 2021Article
- FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research.Development (Cambridge, England) · 2020Review
- Zebrafish (Danio rerio) physiological and behavioural responses to insect-based diets: a multidisciplinary approach.Scientific reports · 2020Article
- A six-months study on Black Soldier Fly (Hermetia illucens) based diets in zebrafish.Scientific reports · 2019Article
- Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Conserved but flexible modularity in the zebrafish skull: implications for craniofacial evolvability.Proceedings. Biological sciences · 2018Article
- The skeletal ontogeny of Astatotilapia burtoni - a direct-developing model system for the evolution and development of the teleost body plan.BMC developmental biology · 2018Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Fishes are wonderfully diverse. This variety is a result of the ability of ray-finned fishes to adapt to a wide range of environments, and has made them more specious than the rest of vertebrates combined. With such diversity it is easy to dismiss comparisons between distantly related fishes in efforts to understand the biology of a particular fish species. However, shared ancestry and the conservation of developmental mechanisms, morphological features and physiology provide the ability to use comparative analyses between different organisms to understand mechanisms of development and physiology. The use of species that are amenable to experimental investigation provides tools to approach questions that would not be feasible in other 'non-model' organisms. For example, the use of small teleost fishes such as zebrafish and medaka has been powerful for analysis of gene function and mechanisms of disease in humans, including skeletal diseases. However, use of these fish to aid in understanding variation and disease in other fishes has been largely unexplored. This is especially evident in aquaculture research. Here we highlight the utility of these small laboratory fishes to study genetic and developmental factors that underlie skeletal malformations that occur under farming conditions. We highlight several areas in which model species can serve as a resource for identifying the causes of variation in economically important fish species as well as to assess strategies to alleviate the expression of the variant phenotypes in farmed fish. We focus on genetic causes of skeletal deformities in the zebrafish and medaka that closely resemble phenotypes observed both in farmed as well as natural populations of fishes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.