Trial reportThe American journal of psychiatry2014
Clinical outcomes and genome-wide association for a brain methylation site in an antidepressant pharmacogenetics study in Mexican Americans.
Trial report in The American journal of psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Genetic variation associated with depression in Latin American populations: a systematic review of single-nucleotide variants.Frontiers in psychiatry · 2026Pooled it
- Rare Functional Variants Associated with Antidepressant Remission in Mexican-Americans: Short title: Antidepressant remission and pharmacogenetics in Mexican-Americans.Journal of affective disorders · 2021Trial
- A latent genetic subtype of major depression identified by whole-exome genotyping data in a Mexican-American cohort.Translational psychiatry · 2017Trial
- Impulsive and Omission Errors: Potential Temporal Processing Endophenotypes in ADHD.Brain sciences · 2021Article
- Genetic Markers for Later Remission in Response to Early Improvement of Antidepressants.International journal of molecular sciences · 2020Article
- Targeted exome sequencing identifies five novel loci at genome-wide significance for modulating antidepressant response in patients with major depressive disorder.Translational psychiatry · 2020Article
- A Review of Mental Health and Mental Health Care Disparities Research: 2011-2014.Medical care research and review : MCRR · 2019Review
- Pharmacogenetics and Depression: A Critical Perspective.Psychiatry investigation · 2019Article
- Article
- Low-frequency and rare variants may contribute to elucidate the genetics of major depressive disorder.Translational psychiatry · 2018Article
- The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF.Scientific reports · 2018Article
- The PHF21B gene is associated with major depression and modulates the stress response.Molecular psychiatry · 2017Article
- Whole-genome single nucleotide variant distribution on genomic regions and its relationship to major depression.Psychiatry research · 2017Article
- Biological and behavioural antidepressant treatment responses with the selective serotonin reuptake inhibitor fluoxetine can be determined by the environment.Molecular psychiatry · 2017Article
- Single-nucleotide variant proportion in genes: a new concept to explore major depression based on DNA sequencing data.Journal of human genetics · 2017Article
- A novel strategy for clustering major depression individuals using whole-genome sequencing variant data.Scientific reports · 2017Article
- Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate.Molecular psychiatry · 2016Article
- Personalized prescribing: a new medical model for clinical implementation of psychotropic drugs.Dialogues in clinical neuroscience · 2016Review
- APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease.Molecular psychiatry · 2016Article
- Molecular psychiatry: 20 years.Molecular psychiatry · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe authors compared the effectiveness of fluoxetine and desipramine treatment in a prospective double-blind pharmacogenetics study in first-generation Mexican Americans and examined the role of whole-exome functional gene variations in the patients' antidepressant response.
methodA total of 232 Mexican Americans who met DSM-IV criteria for major depressive disorder were randomly assigned to receive 8 weeks of double-blind treatment with desipramine (50-200 mg/day) or fluoxetine (10-40 mg/day) after a 1-week placebo lead-in period. Outcome measures included the Hamilton Depression Rating Scale (HAM-D), the Hamilton Anxiety Rating Scale, and the Beck Depression Inventory. At week 8, whole-exome genotyping data were obtained for 36 participants who remitted and 29 who did not respond to treatment.
resultsCompared with desipramine treatment, fluoxetine treatment was associated with a greater reduction in HAM-D score, higher response and remission rates, shorter time to response and remission, and lower incidences of anticholinergic and cardiovascular side effects. Pharmacogenetics analysis showed that exm-rs1321744 achieved exome-wide significance for treatment remission. This variant is located in a brain methylated DNA immunoprecipitation sequencing site, which suggests that it may be involved in epigenetic regulation of neuronal gene expression. This and two other common gene variants provided a highly accurate cross-validated predictive model for treatment remission of major depression (receiver operating characteristic integral=0.95).
conclusionsCompared with desipramine, fluoxetine treatment showed a more rapid reduction of HAM-D score and a lower incidence of side effects in a population comprising primarily first-generation Mexican Americans with major depression. This study's pharmacogenetics approach strongly implicates the role of functional variants in antidepressant treatment response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.