ArticleArthritis & rheumatology (Hoboken, N.J.)2014
Altered functional magnetic resonance imaging responses to nonpainful sensory stimulation in fibromyalgia patients.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Role of non-invasive objective markers for the rehabilitative diagnosis of central sensitization in patients with fibromyalgia: A systematic review.Journal of back and musculoskeletal rehabilitation · 2024Pooled it
- Coordinate-based (ALE) meta-analysis of brain activation in patients with fibromyalgia.Human brain mapping · 2016Pooled it
- Auditory Hyperresponsivity in Chronic Back Pain: A Randomized Controlled Trial of Pain Reprocessing Therapy.Annals of neurology · 2026Trial
- Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia.Neuromodulation : journal of the International Neuromodulation Society · 2023Trial
- Prediction of Differential Pharmacologic Response in Chronic Pain Using Functional Neuroimaging Biomarkers and a Support Vector Machine Algorithm: An Exploratory Study.Arthritis & rheumatology (Hoboken, N.J.) · 2021Trial
- Effects of intensity, attention and medication on auditory-evoked potentials in patients with fibromyalgia.Scientific reports · 2020Trial
- Testing the effects of gentle vibrotactile stimulation on symptom relief in fibromyalgia.Arthritis research & therapy · 2019Trial
- Effects ofPain reports · 2026Article
- Generalized Sensory Sensitivity in Patients With Urinary Urgency-A LURN II Urinary Urgency Phenotyping Study.The Journal of urology · 2026Article
- Article
- Visual Hypersensitivity as a Transdiagnostic Marker of Surgical Pain Response in Arthritis and Chronic Pain Syndromes.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Effects of electroacupuncture at Zusanli on pain-perception-related brain nuclei in KOA mice: a study on cortical and subcortical c-fos expression.Behavioral and brain functions : BBF · 2026Article
- Brain-immune correlates of quality of life in adolescents with chronic musculoskeletal pain.Brain, behavior, and immunity · 2026Article
- Brain sensory network activity underlies reduced nociceptive initiated and nociplastic pain via acupuncture in fibromyalgia.Communications medicine · 2026Article
- Machine learning for the diagnosis of fibromyalgia based on magnetic resonance imaging.PloS one · 2026Article
- A neuropsychological perspective on sensory hypersensitivity after acquired brain injury.Brain communications · 2026Review
- Brain Sensory Network Activity Underlies Reduced Nociceptive-Initiated and Nociplastic Pain via Acupuncture in Fibromyalgia.Research square · 2025Article
- Patient subtyping in juvenile fibromyalgia: the role of multisensory hypersensitivity and neurophysiological correlates.Journal of pediatric psychology · 2025Article
- Multimodal hypersensitivity and somatic symptoms predict adolescent postmenarchal widespread pain.Pain · 2025Article
- Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
Abstract
objectiveFibromyalgia (FM) is a disorder characterized by chronic pain and enhanced responses to acute noxious events. However, the sensory systems affected in FM may extend beyond pain itself, as FM patients show reduced tolerance to non-nociceptive sensory stimulation. Characterizing the neural substrates of multisensory hypersensitivity in FM may thus provide important clues about the underlying pathophysiology of the disorder. The aim of this study was to characterize brain responses to non-nociceptive sensory stimulation in FM patients and their relationship to subjective sensory sensitivity and clinical pain severity.
methodsFunctional magnetic resonance imaging (MRI) was used to assess brain response to auditory, visual, and tactile motor stimulation in 35 women with FM and 25 matched controls. Correlation and mediation analyses were performed to establish the relationship between brain responses and 3 types of outcomes: subjective hypersensitivity to daily sensory stimulation, spontaneous pain, and functional disability.
resultsPatients reported increased subjective sensitivity (increased unpleasantness) in response to multisensory stimulation in daily life. Functional MRI revealed that patients showed reduced task-evoked activation in primary/secondary visual and auditory areas and augmented responses in the insula and anterior lingual gyrus. Reduced responses in visual and auditory areas were correlated with subjective sensory hypersensitivity and clinical severity measures.
conclusionFM patients showed strong attenuation of brain responses to nonpainful events in early sensory cortices, accompanied by an amplified response at later stages of sensory integration in the insula. These abnormalities are associated with core FM symptoms, suggesting that they may be part of the pathophysiology of the disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.