Evidence map›Paper›PMID 25220703›Full record

ArticleNeuroscience letters2014

Endothelin-1 induced desensitization in primary afferent neurons.

Terika P Smith, Sherika N Smith, Sarah M Sweitzer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Terika P SmithDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina, Columbia, SC, United States. Electronic address: Terika.Smith@uscmed.sc.edu.
Sherika N SmithDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina, Columbia, SC, United States.
Sarah M SweitzerDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina, Columbia, SC, United States; College of Health and Human Services, Concordia University, Portland, OR, United States.
University of South Carolina · USConcordia University · US

Funding

INJURY-INDUCES PAIN-- CHEMICAL MODULATION OF NOCICEPTORSR01NS026363 · NINDS · JOHNS HOPKINS UNIVERSITY · PI RAJA, SRINIVASA N. · 1989 to 2021
$6.8M
UofSC Postbaccalaureate Research Education ProgramR25GM066526 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ARMSTRONG, ALISSA RICHMOND, ELY, BERT · 2004 to 2024
$5.4M
University of South Carolina Initiative for Maximizing Student DevelopmentR25GM076277 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ELY, BERT · 2006 to 2015
$2.6M
Developmental regulation of endothelin painR01DA023593 · NIDA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SWEITZER, SARAH M · 2008 to 2011
$1.0M
NIDA NIH HHS R01 DA023593NIGMS NIH HHS R25 GM066526NIGMS NIH HHS R25GM066526NIGMS NIH HHS R25 GM076277NINDS NIH HHS NS26363NINDS NIH HHS R01 NS026363
6 · The paper itself

Abstract

Endothelin-1 (ET-1) is a known algogen that causes acute pain and sensitization in humans and spontaneous nociceptive behaviors when injected into the periphery in rats, and is elevated during vaso-occlusive episodes (VOEs) in sickle cell disease (SCD) patients. Previously, our lab has shown that a priming dose of ET-1 produces sensitization to capsaicin-induce secondary hyperalgesia. The goal of this study was to determine if the sensitization induced by ET-1 priming is occurring at the level of the primary afferent neuron. Calcium imaging in cultured dorsal root ganglion (DRG) neurons was utilized to examine the effects of ET-1 on primary afferent neurons. ET-1 induces [Ca(2+)]i transients in unprimed cells. ET-1 induced [Ca(2+)]i transients are attenuated by priming with ET-1. This priming effect occurs whether the priming dose is given 0-4 days prior to the challenge dose. Similarly, ET-1 priming decreases capsaicin-induced [Ca(2+)]i transients. At the level of the primary afferent neuron, ET-1 priming has a desensitizing effect on challenge exposures to ET-1 and capsaicin.

Indexed as

AnimalsCalciumCapsaicinEndothelin-1Ganglia, SpinalMaleNeurons, AfferentPrimary Cell CultureRats, Sprague-DawleySensory System AgentsCalciumCapsaicinEndothelin-1Sensory System AgentsCalcium transientsCapsaicinDorsal root gangliaEndothelin-1(ET-1)

Identifiers

PMID25220703
PMCPMC4209176
OpenAlexW2004153644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.