ArticleDevelopmental biology2014
Chibby functions in Xenopus ciliary assembly, embryonic development, and the regulation of gene expression.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis.Scientific reports · 2021Article
- Polarized Sonic Hedgehog Protein Localization and a Shift in the Expression of Region-Specific Molecules Is Associated With the Secondary Palate Development in the Veiled Chameleon.Frontiers in cell and developmental biology · 2020Article
- Developmentally regulated GTP-binding protein 1 modulates ciliogenesis via an interaction with Dishevelled.The Journal of cell biology · 2019Article
- Article
- Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation.PLoS genetics · 2017Article
- Nuclear roles for cilia-associated proteins.Cilia · 2017Review
- BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis.Molecular and cellular biology · 2016Article
- Transition zone assembly and its contribution to axoneme formation in Drosophila male germ cells.The Journal of cell biology · 2016Article
- Identifying domains of EFHC1 involved in ciliary localization, ciliogenesis, and the regulation of Wnt signaling.Developmental biology · 2016Article
- Centrin-2 (Cetn2) mediated regulation of FGF/FGFR gene expression in Xenopus.Scientific reports · 2015Article
- Chibby functions to preserve normal ciliary morphology through the regulation of intraflagellar transport in airway ciliated cells.Cell cycle (Georgetown, Tex.) · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Wnt signaling and ciliogenesis are core features of embryonic development in a range of metazoans. Chibby (Cby), a basal-body associated protein, regulates β-catenin-mediated Wnt signaling in the mouse but not Drosophila. Here we present an analysis of Cby's embryonic expression and morphant phenotypes in Xenopus laevis. Cby RNA is supplied maternally, negatively regulated by Snail2 but not Twist1, preferentially expressed in the neuroectoderm, and regulates β-catenin-mediated gene expression. Reducing Cby levels reduced the density of multiciliated cells, the number of basal bodies per multiciliated cell, and the numbers of neural tube primary cilia; it also led to abnormal development of the neural crest, central nervous system, and pronephros, all defects that were rescued by a Cby-GFP chimera. Reduction of Cby led to an increase in Wnt8a and decreases in Gli2, Gli3, and Shh RNA levels. Many, but not all, morphant phenotypes were significantly reversed by the Wnt inhibitor SFRP2. These observations extend our understanding of Cby's role in mediating the network of interactions between ciliogenesis, signaling systems and tissue patterning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.