ArticleHuman brain mapping2015
BDNF Val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC]).Translational behavioral medicine · 2019Trial
- Moderating Effects of Genetic Polymorphisms on Improvements in Cognitive Impairment in Breast Cancer Survivors Participating in a 6-Week Mindfulness-Based Stress Reduction Program.Biological research for nursing · 2015Trial
- Spiritual walking and stress resilience integrating psychological endocrine and genetic evidence from a longitudinal Iraqi cohort.Discover mental health · 2026Article
- Probiotics and the Gut-Brain Axis: Emerging Therapeutic Strategies for Epilepsy and Depression Comorbidity.Foods (Basel, Switzerland) · 2025Review
- No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state.Clinical epigenetics · 2024Article
- Serotonin 4 receptor brain binding and oxytocin-promoted affective and social cognition in healthy women - A randomized controlled trial.Comprehensive psychoneuroendocrinology · 2024Article
- Low-grade inflammation and serotonin 4 receptor binding in the healthy and the depressed brain.Neuroscience applied · 2024Article
- Genetic contributions to brain serotonin transporter levels in healthy adults.Scientific reports · 2023Article
- Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction.JAMA psychiatry · 2023Article
- Translational Genomic Research: The Association between Genetic Profiles and Cognitive Functioning or Cardiac Function Among Breast Cancer Survivors Completing Chemotherapy.Biological research for nursing · 2022Article
- Concurrent anxiety in patients with major depression and cerebral serotonin 4 receptor binding. A NeuroPharm-1 study.Translational psychiatry · 2022Article
- Article
- The Impact of Hormonal Contraceptive Use on Serotonergic Neurotransmission and Antidepressant Treatment Response: Results From the NeuroPharm 1 Study.Frontiers in endocrinology · 2022Article
- Oral contraceptives and the serotonin 4 receptor: a molecular brain imaging study in healthy women.Acta psychiatrica Scandinavica · 2020Article
- Covariance statistics and network analysis of brain PET imaging studies.Scientific reports · 2019Article
- Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression.Translational psychiatry · 2019Article
- High brain serotonin levels in migraine between attacks: A 5-HTNeuroImage. Clinical · 2018Article
- Brain serotonin 4 receptor binding is inversely associated with verbal memory recall.Brain and behavior · 2017Article
- BDNF val66met association with serotonin transporter binding in healthy humans.Translational psychiatry · 2017Article
- No evidence for a role of the serotonin 4 receptor in five-factor personality traits: A positron emission tomography brain study.PloS one · 2017Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain-derived neurotrophic factor (BDNF) has been implicated in multiple aspects of brain function including regulation of serotonin signaling. The BDNF val66met polymorphism (rs6265) has been linked to aspects of serotonin signaling in humans but its effects are not well understood. To address this, we evaluated whether BDNF val66met was predictive of a putative marker of brain serotonin levels, serotonin 4 receptor (5-HT4 ) binding assessed with [11C]SB207145 positron emission tomography, which has also been associated with the serotonin-transporter-linked polymorphic region (5-HTTLPR) polymorphism. We applied a linear latent variable model (LVM) using regional 5-HT4 binding values (neocortex, amygdala, caudate, hippocampus, and putamen) from 68 healthy humans, allowing us to explicitly model brain-wide and region-specific genotype effects on 5-HT4 binding. Our data supported an LVM wherein BDNF val66met significantly predicted a LV reflecting [11C]SB207145 binding across regions (P = 0.005). BDNF val66met met-carriers showed 2-9% higher binding relative to val/val homozygotes. In contrast, 5-HTTLPR did not predict the LV but S-carriers showed 7% lower neocortical binding relative to LL homozygotes (P = 7.3 × 10(-6)). We observed no evidence for genetic interaction. Our findings indicate that BDNF val66met significantly predicts a common regulator of brain [11C]SB207145 binding, which we hypothesize reflects brain serotonin levels. In contrast, our data indicate that 5-HTTLPR specifically affects 5-HT4 binding in the neocortex. These findings implicate serotonin signaling as an important molecular mediator underlying the effects of BDNF val66met and 5-HTTLPR on behavior and related risk for neuropsychiatric illness in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.