Evidence map›Paper›PMID 25220071›Full record

ReviewDeutsches Arzteblatt international2014

Ocular changes during pregnancy.

Friederike Mackensen, Wolfgang E Paulus, Regina Max, Thomas Ness

Abstract readReview
In one paragraph

Review in Deutsches Arzteblatt international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Diabetic Retinopathy during pregnancy in Hispanic women with latent Toxoplasma gondii infection.European journal of obstetrics, gynecology, and reproductive biology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Changes in Refractive and Optometric Findings During Pregnancy.Medical journal of the Islamic Republic of Iran · 2022
    Article
  15. Article
  16. [Bilateral posterior serous retinal detachment associated with HELLP syndrome].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021
    Article
  17. Observational
  18. Article
  19. Review
  20. Evaluation of the Choroid in Women with Uncomplicated Pregnancy.Translational vision science & technology · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Friederike MackensenInterdisciplinary Uveitis Center, Department of Ophthalmology, University of Heidelberg, Institute of Reproductive Toxicology Ravensburg, Department of Internal Medicine V, Department of Ophthalmology, University of Freiburg i. Brsg.
Wolfgang E Paulus
Regina Max
Thomas Ness

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost ocular changes in pregnancy are harmless. For example, 14% of pregnant women need a new eyeglass prescription. Some changes, however, are serious, such as retinal effects of hypertension, which can be a sign of pre-eclampsia. Ocular changes may give rise to uncertainty about the administration of ophthalmological drugs or the optimal method of childbirth.

methodThis review is based on pertinent literature retrieved by a selective search in Medline and on guidelines from Germany and abroad. Recommendations about drugs were taken from the Embryotox and Reprotox databases, the German Red List, and the United States Food and Drug Administration (FDA).

results40% to 100% of pregnant women with high blood pressure have retinal changes whose severity is correlated with the severity of pre-eclampsia or eclampsia. Diabetic women should undergo ocular examination before and during pregnancy. Pre-existing retinal changes worsen during pregnancy in 55% of cases. Most ocular diseases can be treated with the usual drugs in pregnant women and nursing mothers, although the evidence for drug safety is derived from case series and the treatment is usually provided off label. Ocular conditions that are present before pregnancy are irrelevant to the choice of a method of childbirth.

conclusionPregnant women and nursing mothers can undergo most types of ophthalmological examination and treatment. Recommendations about drug treatment should be checked against current information that can be found on the embryotox.de and reprotox.de websites.

Indexed as

Practice Guidelines as TopicDiagnostic Techniques, OphthalmologicalEye DiseasesFemaleHumansPregnancyPregnancy Complications

Identifiers

PMID25220071
PMCPMC4165189

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.