ArticleCurrent biology : CB2014
The logic of circadian organization in Drosophila.
Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Behavioral adaptation to warm conditions via Lim1-mediated acceleration of neuronal clocks.Nature neuroscience · 2026Article
- Cryptochrome interaction networks across different tissues in Drosophila melanogaster.Biology direct · 2025Article
- Circuit analysis of theNetwork neuroscience (Cambridge, Mass.) · 2023Article
- Review
- Decapentaplegic Acutely Defines the Connectivity of Central Pacemaker Neurons inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Uncovering the Roles of Clocks and Neural Transmission in the Resilience ofFrontiers in physiology · 2021Article
- Article
- Molecular mechanisms and physiological importance of circadian rhythms.Nature reviews. Molecular cell biology · 2020Review
- Disrupted Glutamate Signaling inFrontiers in physiology · 2020Article
- Entrainment of theNeuroscience insights · 2020Review
- Article
- Article
- Contribution of non-circadian neurons to the temporal organization of locomotor activity.Biology open · 2019Article
- Locomotor Behaviour and Clock Neurons Organisation in the Agricultural PestFrontiers in physiology · 2019Article
- Circadian Rhythm Abnormalities in Parkinson's Disease from Humans to Flies and Back.International journal of molecular sciences · 2018Review
- Reconfiguration of a Multi-oscillator Network by Light in the Drosophila Circadian Clock.Current biology : CB · 2018Article
- Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior.Cold Spring Harbor perspectives in biology · 2018Review
- Article
- A Series of Suppressive Signals within the Drosophila Circadian Neural Circuit Generates Sequential Daily Outputs.Neuron · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundIn the fruit fly Drosophila melanogaster, interlocked negative transcription/translation feedback loops provide the core of the circadian clock that generates rhythmic phenotypes. Although the current molecular model portrays the oscillator as cell autonomous, cross-talk among clock neurons is essential for robust cycling behavior. Nevertheless, the functional organization of the neuronal network remains obscure.
resultsHere we show that shortening or lengthening of the circadian period of locomotor activity can be obtained either by targeting different groups of clock cells with the same genetic manipulation or by challenging the same group of cells with activators and repressors of neuronal excitability.
conclusionsBased on these observations we interpret circadian rhythmicity as an emerging property of the circadian network and we propose an initial model for its architectural design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.