ArticleCurrent biology : CB2014
Pulsatile dynamics in the yeast proteome.
Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 78 citations in OpenAlex.
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- Biological physics to uncover cell signaling.Biophysical reviews · 2025Review
- Amplitude and frequency encoding result in qualitatively distinct informational landscapes in cell signaling.Scientific reports · 2025Article
- Quantifying the nuclear localization of fluorescently tagged proteins.Bioinformatics advances · 2025Article
- Phenotypic heterogeneity follows a growth-viability tradeoff in response to amino acid identity.Nature communications · 2024Article
- The CRZ1 transcription factor in plant fungi: regulation mechanism and impact on pathogenesis.Molecular biology reports · 2024Review
- Energy metabolism modulates the regulatory impact of activators on gene expression.Development (Cambridge, England) · 2024Article
- Energy metabolism modulates the regulatory impact of activators on gene expression.bioRxiv : the preprint server for biology · 2023Article
- Transcription factor localization dynamics and DNA binding drive distinct promoter interpretations.Cell reports · 2023Article
- Identification and Characterization of Dmct: A Cation Transporter inJournal of fungi (Basel, Switzerland) · 2023Article
- Modulation of transcription factor dynamics allows versatile information transmission.Scientific reports · 2023Article
- Interaction of calcium responsive proteins and transcriptional factors with the PHO regulon in yeasts and fungi.Frontiers in cell and developmental biology · 2023Review
- Frequency modulation of a bacterial quorum sensing response.Nature communications · 2022Article
- Temporal signaling, population control, and information processing through chromatin-mediated gene regulation.Journal of theoretical biology · 2022Article
- Mapping the dynamic transfer functions of eukaryotic gene regulation.Cell systems · 2021Article
- Progress and challenges in understanding the regulation and function of p53 dynamics.Biochemical Society transactions · 2021Review
- Correlative single-molecule fluorescence barcoding of gene regulation in Saccharomyces cerevisiae.Methods (San Diego, Calif.) · 2021Article
- Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs.Nature communications · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The activation of transcription factors in response to environmental conditions is fundamental to cellular regulation. Recent work has revealed that some transcription factors are activated in stochastic pulses of nuclear localization, rather than at a constant level, even in a constant environment [1-12]. In such cases, signals control the mean activity of the transcription factor by modulating the frequency, duration, or amplitude of these pulses. Although specific pulsatile transcription factors have been identified in diverse cell types, it has remained unclear how prevalent pulsing is within the cell, how variable pulsing behaviors are between genes, and whether pulsing is specific to transcriptional regulators or is employed more broadly. To address these issues, we performed a proteome-wide movie-based screen to systematically identify localization-based pulsing behaviors in Saccharomyces cerevisiae. The screen examined all genes in a previously developed fluorescent protein fusion library of 4,159 strains [13] in multiple media conditions. This approach revealed stochastic pulsing in ten proteins, all transcription factors. In each case, pulse dynamics were heterogeneous and unsynchronized among cells in clonal populations. Pulsing is the only dynamic localization behavior that we observed, and it tends to occur in pairs of paralogous and redundant proteins. Taken together, these results suggest that pulsatile dynamics play a pervasive role in yeast and may be similarly prevalent in other eukaryotic species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.