Evidence map›Paper›PMID 25219811›Full record

ReviewSeminars in radiation oncology2014

New considerations in radiation treatment planning for brain tumors: neural progenitor cell-containing niches.

Carmen Kut, Kristin Janson Redmond

Erratum issuedOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in radiation oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Dosimetric advantages of proton therapy over conventional radiotherapy with photons in young patients and adults with low-grade glioma.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2016
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Glioblastoma recurrence patterns near neural stem cell regions.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2015
    Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Carmen KutDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, The Johns Hopkins University, Baltimore, MD.
Kristin Janson RedmondDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, The Johns Hopkins University, Baltimore, MD. Electronic address: kjanson3@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
OCT to Distinguish b/t Tumor & Non-Tumor Tissue in Infiltrating Brain CancerF30CA183430 · NCI · JOHNS HOPKINS UNIVERSITY · PI KUT, CARMEN · 2014 to 2016
$144k
NCI NIH HHS F30 CA183430NIGMS NIH HHS T32 GM007309
6 · The paper itself

Abstract

The purpose of this critical review is to explore the controversy regarding the relationship between radiation dose to the neural progenitor cell (NPC) niches and patient outcomes, in terms of both toxicity and tumor control. NPCs in the subventricular zone (SVZ) and hippocampus are paradoxically associated with long-term neurocognitive sequelae of brain irradiation, as well as resistance to therapy and tumor recurrence. The reconciliation of these somewhat opposing functions is challenging. Current literature suggests that radiation and other treatments against the NPC in the hippocampus and the SVZ may influence patient outcome. As a result, both the SVZ and the hippocampus could have important implications on radiation treatment planning strategies, and future laboratory and clinical evaluations will be critical in designing studies to optimize treatment outcome, effectiveness, and safety.

Indexed as

BrainBrain NeoplasmsCranial IrradiationHumansNeural Stem CellsRadiotherapy DosageRadiotherapy Planning, Computer-AssistedStem Cell Niche

Identifiers

PMID25219811
PMCPMC4467686
OpenAlexW2130743422

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.