ArticleInternational journal of obesity (2005)2015
L-cysteine suppresses ghrelin and reduces appetite in rodents and humans.
Article in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Wheat Biscuits Enriched with Plant-Based Protein Contribute to Weight Loss and Beneficial Metabolic Effects in Subjects with Overweight/Obesity.Nutrients · 2022Trial
- Sulfide regulation and catabolism in health and disease.Signal transduction and targeted therapy · 2025Review
- Potential of Vitamin D and l-Cysteine Co-supplementation to Downregulate Mammalian Target of Rapamycin: A Novel Therapeutic Approach to Diabetes.Metabolic syndrome and related disorders · 2025Review
- A comprehensive overview of the effects of probiotics, prebiotics and synbiotics on the gut-brain axis.Frontiers in microbiology · 2025Review
- Gut peptides and the microbiome: focus on ghrelin.Current opinion in endocrinology, diabetes, and obesity · 2021Review
- Specific amino acids but not total protein attenuate postpartum weight gain among Hispanic women from Southern California.Food science & nutrition · 2021Article
- Evaluation of an Amino Acid Mix on the Secretion of Gastrointestinal Peptides, Glucometabolic Homeostasis, and Appetite in Obese Adolescents Administered with a Fixed-Dose or ad Libitum Meal.Journal of clinical medicine · 2020Article
- L-Arginine Increases Postprandial Circulating GLP-1 and PYY Levels in Humans.Obesity (Silver Spring, Md.) · 2018Article
- Hydrogen sulfide suppresses ghrelin secretion in vitro and delays postprandial ghrelin secretion while reducing appetite in mice.Physiological reports · 2018Article
- Hippocampus ghrelin receptor signaling promotes socially-mediated learned food preference.Neuropharmacology · 2018Article
- l-phenylalanine modulates gut hormone release and glucose tolerance, and suppresses food intake through the calcium-sensing receptor in rodents.International journal of obesity (2005) · 2017Article
- Correlation Between Gastric Emptying and Gastric Adaptive Relaxation Influenced by Amino Acids.Journal of neurogastroenterology and motility · 2017Article
- Comparisons of l-cysteine and d-cysteine toxicity in 4-week repeated-dose toxicity studies of rats receiving daily oral administration.Journal of toxicologic pathology · 2017Article
- Effects of intraperitoneally administered L-histidine on food intake, taste, and visceral sensation in rats.The journal of physiological sciences : JPS · 2017Article
- Article
- Patterned feeding induces neuroendocrine, behavioral and genetic changes that promote palatable food intake.International journal of obesity (2005) · 2017Article
- Rice Bran and Probiotics Alter the Porcine Large Intestine and Serum Metabolomes for Protection against Human Rotavirus Diarrhea.Frontiers in microbiology · 2017Article
- L-arginine promotes gut hormone release and reduces food intake in rodents.Diabetes, obesity & metabolism · 2016Article
- Cysteine and hydrogen sulphide in the regulation of metabolism: insights from genetics and pharmacology.The Journal of pathology · 2016Review
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundHigh-protein diets promote weight loss and subsequent weight maintenance, but are difficult to adhere to. The mechanisms by which protein exerts these effects remain unclear. However, the amino acids produced by protein digestion may have a role in driving protein-induced satiety.
methodsWe tested the effects of a range of amino acids on food intake in rodents and identified l-cysteine as the most anorexigenic. Using rodents we further studied the effect of l-cysteine on food intake, behaviour and energy expenditure. We proceeded to investigate its effect on neuronal activation in the hypothalamus and brainstem before investigating its effect on gastric emptying and gut hormone release. The effect of l-cysteine on appetite scores and gut hormone release was then investigated in humans.
resultsl-Cysteine dose-dependently decreased food intake in both rats and mice following oral gavage and intraperitoneal administration. This effect did not appear to be secondary to behavioural or aversive side effects. l-Cysteine increased neuronal activation in the area postrema and delayed gastric emptying. It suppressed plasma acyl ghrelin levels and did not reduce food intake in transgenic ghrelin-overexpressing mice. Repeated l-cysteine administration decreased food intake in rats and obese mice. l-Cysteine reduced hunger and plasma acyl ghrelin levels in humans.
conclusionsFurther work is required to determine the chronic effect of l-cysteine in rodents and humans on appetite and body weight, and whether l-cysteine contributes towards protein-induced satiety.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.