ArticleHearing research2014
Prolonged noise exposure-induced auditory threshold shifts in rats.
Article in Hearing research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Resveratrol Mitigates Noise-Induced Cochlear Damage and Delays Hearing Loss in Wistar Rats.BioMed research international · 2026Article
- Noise-induced vestibular dysfunction in rats: longitudinal assessment using cVEMP and behavioral testing after low-frequency acoustic trauma.Frontiers in integrative neuroscience · 2025Article
- Sex differences in body composition, voluntary wheel running activity, balance performance, and auditory function in CBA/CaJ mice across the lifespan.Hearing research · 2023Article
- Killer or helper? The mechanism underlying the role of adenylate activated kinase in sound conditioning.Frontiers in synaptic neuroscience · 2022Article
- Hearing impairment in murine model of Down syndrome.Frontiers in genetics · 2022Article
- Dynamic Changes in Synaptic Plasticity Genes in Ipsilateral and Contralateral Inferior Colliculus Following Unilateral Noise-induced Hearing Loss.Neuroscience · 2020Article
- Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice.Experimental gerontology · 2020Article
- Novel oral multifunctional antioxidant prevents noise-induced hearing loss and hair cell loss.Hearing research · 2020Article
- Noise-Induced loudness recruitment and hyperacusis: Insufficient central gain in auditory cortex and amygdala.Neuroscience · 2019Article
- Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice.Experimental gerontology · 2019Article
- Impacts of Subchronic, High-Level Noise Exposure on Sleep and Metabolic Parameters: A Juvenile Rodent Model.Environmental health perspectives · 2019Article
- Synaptic Reorganization Response in the Cochlear Nucleus Following Intense Noise Exposure.Neuroscience · 2019Article
- Prolonged low-level noise exposure reduces rat distortion product otoacoustic emissions above a critical level.Hearing research · 2018Article
- Auditory central gain compensates for changes in cochlear output after prolonged low-level noise exposure.Neuroscience letters · 2018Article
- Hidden cochlear impairments.Journal of otology · 2018Review
- Hidden Age-Related Hearing Loss and Hearing Disorders: Current Knowledge and Future Directions.Hearing, balance and communication · 2018Article
- Work-Related Noise Exposure in a Cohort of Patients with Chronic Tinnitus: Analysis of Demographic and Audiological Characteristics.International journal of environmental research and public health · 2017Article
- Noise-induced hearing loss induces loudness intolerance in a rat Active Sound Avoidance Paradigm (ASAP).Hearing research · 2017Article
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Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Noise-induced hearing loss (NIHL) initially increases with exposure duration, but eventually reaches an asymptotic threshold shift (ATS) once the exposure duration exceeds 18-24 h. Equations for predicting the ATS have been developed for several species, but not for rats, even though this species is extensively used in noise exposure research. To fill this void, we exposed rats to narrowband noise (NBN, 16-20 kHz) for 5 weeks starting at 80 dB SPL in the first week and then increasing the level by 6 dB per week to a final level of 104 dB SPL. Auditory brainstem responses (ABR) were recorded before, during, and following the exposure to determine the amount of hearing loss. The noise induced threshold shift to continuous long-term exposure, defined as compound threshold shift (CTS), within and above 16-20 kHz increased with noise level at the rate of 1.82 dB threshold shift per dB of noise level (NL) above a critical level (C) of 77.2 dB SPL i.e. CTS = 1.82(NL-77.2). The normalized amplitude of the largest ABR peak measured at 100 dB SPL decreased at the rate of 3.1% per dB of NL above the critical level of 76.9 dB SPL, i.e., %ABR Reduction = 3.1%(NL-76.9). ABR thresholds measured >30 days post-exposure only partially recovered resulting in a permanent threshold shift of 30-40 dB along with severe hair cell loss in the basal, high-frequency region of the cochlea. In the rat, CTS increases with noise level with a slope similar to humans and chinchillas. The critical level (C) in the rat is similar to that of humans, but higher than that of chinchillas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.