ArticleInternational journal of obesity (2005)2014
Reference values of whole-blood fatty acids by age and sex from European children aged 3-8 years.
Article in International journal of obesity (2005), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Is high oily fish intake achievable and how does it affect nutrient status in 8-9-year-old children?: the FiSK Junior trial.European journal of nutrition · 2020Trial
- Whole blood fatty acid profile of young subjects and adherence to the Mediterranean diet: an observational cohort study.Lipids in health and disease · 2022Observational
- Fatty acid uptake inFrontiers in cellular and infection microbiology · 2022Review
- Blood Fatty Acids Profile in MIS-C Children.Metabolites · 2021Article
- Article
- Association of Whole Blood Fatty Acids and Growth in Southern Ghanaian Children 2⁻6 Years of Age.Nutrients · 2018Article
- Article
- Blood fatty acid composition in relation to allergy in children aged 2-9 years: results from the European IDEFICS study.European journal of clinical nutrition · 2017Article
- Heart Rate and Blood Pressure Centile Curves and Distributions by Age of Hospitalized Critically Ill Children.Frontiers in pediatrics · 2017Article
- DHA Effects in Brain Development and Function.Nutrients · 2016Review
- Article
- Dried blood spot omega-3 and omega-6 long chain polyunsaturated fatty acid levels in 7-9 year old Zimbabwean children: a cross sectional study.BMC clinical pathology · 2016Article
- Article
- Analysis of breast milk fatty acid composition using dried milk samples.International breastfeeding journal · 2016Article
Corrections and comments
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Authors and funding
15 authors at 11 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo establish reference values for fatty acids (FA) especially for n-3 and n-6 long-chain polyunsaturated FAs (LC PUFA) in whole-blood samples from apparently healthy 3-8-year-old European children. The whole-blood FA composition was analysed and the age- and sex-specific distribution of FA was determined. DESIGN AND SUBJECTS: Blood samples for FA analysis were taken from 2661 children of the IDEFICS (identification and prevention of dietary- and lifestyle-induced health effects in children and infants) study cohort. Children with obesity (n=454) and other diseases that are known to alter the FA composition (n=450) were excluded leaving 1653 participants in the reference population. MEASUREMENTS: The FA composition of whole blood was analysed from blood drops by a rapid, validated gas chromatographic method.
resultsPearson correlation coefficients showed an age-dependent increase of C18:2n-6 and a decrease of C18:1n-9 in a subsample of normal weight boys and girls. Other significant correlations with age were weak and only seen either in boys or in girls, whereas most of the FA did not show any age dependence. For age-dependent n-3 and n-6 PUFA as well as for other FA that are correlated with age (16:0, C18:0 and C18:1n-9) percentiles analysed with the general additive model for location scale and shape are presented. A higher median in boys than in girls was observed for C20:3n-6, C20:4n-6 and C22:4n-6.
conclusionsGiven the reported associations between FA status and health-related outcome, the provision of FA reference ranges may be useful for the interpretation of the FA status of children in epidemiological and clinical studies.
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