Trial reportThe American journal of psychiatry2015
Impact of early intervention on psychopathology, crime, and well-being at age 25.
Trial report in The American journal of psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01653535 (Multisite Prevention of Conduct Problems), which is not on this map. Cited by 74 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multisite Prevention of Conduct Problems
Who cites it
74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 209 citations in OpenAlex.
- What Do We Know About the Stop Now and Plan Program? A Systematic Review and Meta-Analysis of an Early Invention for Children and Youth with Conduct Problems.Prevention science : the official journal of the Society for Prevention Research · 2025Pooled it
- A developmental cascade perspective of paediatric obesity: A systematic review of preventive interventions from infancy through late adolescence.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Pooled it
- Individual-, family-, and school-level interventions targeting multiple risk behaviours in young people.The Cochrane database of systematic reviews · 2018Pooled it
- The randomized controlled trial Fast Track multilevel intervention for children with early-emerging conduct problems breaks intergenerational transmission of violence across three generations.Journal of child psychology and psychiatry, and allied disciplines · 2026Trial
- Randomized controlled trial of the early adolescent coping power program: Effects on emotional and behavioral problems in middle schoolers.Journal of school psychology · 2025Trial
- Targeted Child Mental Health Prevention and Parenting Support Within a Canadian Context: A Randomized Controlled Trial Evaluating the U.S.-Developed Family Check-Up®.Prevention science : the official journal of the Society for Prevention Research · 2025Trial
- Digital Health Delivery of Parenting Skills to Improve Conduct Problems in Middle School Youth Across Two Distinct Randomized Trials.Prevention science : the official journal of the Society for Prevention Research · 2025Trial
- Fast Track Intervention Effects and Mechanisms of Action Through Established Adulthood.Prevention science : the official journal of the Society for Prevention Research · 2025Trial
- Optimizing parenting and child outcomes following parent-child interaction therapy - toddler: a randomized controlled trial.BMC psychology · 2024Trial
- Intergenerational Effects of the Fast Track Intervention on Next-Generation Child Outcomes: A Preregistered Randomized Clinical Trial.The American journal of psychiatry · 2024Trial
- Fast Track intervention effects on family formation.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2023Trial
- Multi-professional and multi-agency model PLUSS to facilitate early detection and support of pre-school children with neurodevelopmental difficulties - a model description.BMC health services research · 2022Trial
- The Fast Track intervention's impact on behaviors of despair in adolescence and young adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2020Trial
- Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African-American Adolescent Alcohol Abuse.Prevention science : the official journal of the Society for Prevention Research · 2018Trial
- Indirect Effects of the Fast Track Intervention on Conduct Disorder Symptoms and Callous-Unemotional Traits: Distinct Pathways Involving Discipline and Warmth.Journal of abnormal child psychology · 2016Trial
- Developmental mediation of genetic variation in response to the Fast Track prevention program.Development and psychopathology · 2015Trial
- Trial
- Annual Research Review: Beyond the target - understanding crossover effects in family-centered prevention.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- School entry health examinations by school nurses for early detection of psychiatric disorders: a prospective cohort study.Child and adolescent psychiatry and mental health · 2026Article
- Implementing a trauma-informed approach in a tiered model of pediatric population mental health care: a pilot study in primary and secondary care.BMC health services research · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThis randomized controlled trial tested the efficacy of early intervention to prevent adult psychopathology and improve well-being in early-starting conduct-problem children.
methodKindergarteners (N=9,594) in three cohorts (1991-1993) at 55 schools in four communities were screened for conduct problems, yielding 979 early starters. A total of 891 (91%) consented (51% African American, 47% European American; 69% boys). Children were randomly assigned by school cluster to a 10-year intervention or control. The intervention goal was to develop social competencies in children that would carry them throughout life, through social skills training, parent behavior-management training with home visiting, peer coaching, reading tutoring, and classroom social-emotional curricula. Manualization and supervision ensured program fidelity. Ninety-eight percent participated during grade 1, and 80% continued through grade 10. At age 25, arrest records were reviewed (N=817, 92%), and condition-blinded adults psychiatrically interviewed participants (N=702; 81% of living participants) and a peer (N=535) knowledgeable about the participant.
resultsIntent-to-treat logistic regression analyses indicated that 69% of participants in the control arm displayed at least one externalizing, internalizing, or substance abuse psychiatric problem (based on self- or peer interview) at age 25, in contrast with 59% of those assigned to intervention (odds ratio=0.59, CI=0.43-0.81; number needed to treat=8). This pattern also held for self-interviews, peer interviews, scores using an "and" rule for self- and peer reports, and separate tests for externalizing problems, internalizing problems, and substance abuse problems, as well as for each of three cohorts, four sites, male participants, female participants, African Americans, European Americans, moderate-risk, and high-risk subgroups. Intervention participants also received lower severity-weighted violent (standardized estimate=-0.37) and drug (standardized estimate=-0.43) crime conviction scores, lower risky sexual behavior scores (standardized estimate=-0.24), and higher well-being scores (standardized estimate=0.19).
conclusionsThis study provides evidence for the efficacy of early intervention in preventing adult psychopathology among high-risk early-starting conduct-problem children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.