SynthesisJournal of autism and developmental disorders2015
Feasibility and effectiveness of very early intervention for infants at-risk for autism spectrum disorder: a systematic review.
Synthesis in Journal of autism and developmental disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
108 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Examining Behavioral Interventions for Infancy and Early Toddlerhood: A Systematic Review of Intervention Effects, Parameters, and Participants.Journal of autism and developmental disorders · 2026Pooled it
- Health Knowledge About Early Diagnosis of Autism Spectrum Disorders: A Case for Soft Transdiagnostic Approaches to Better Represent the Clinical and Scientific Reality of ASD.International journal of environmental research and public health · 2025Pooled it
- Parent-Mediated Interventions for Infants under 24 Months at Risk for Autism Spectrum Disorder: A Systematic Review of Randomized Controlled Trials.Journal of autism and developmental disorders · 2022Pooled it
- Definitions of Nonverbal and Minimally Verbal in Research for Autism: A Systematic Review of the Literature.Journal of autism and developmental disorders · 2020Pooled it
- Programmatic Costs of Project ImPACT for Children with Autism: A Time-Driven Activity Based Costing Study.Administration and policy in mental health · 2023Trial
- Examining a stepped-care telehealth program for parents of young children with autism: a proof-of-concept trial.Molecular autism · 2021Trial
- Promoting social attention in 3-year-olds with ASD through gaze-contingent eye tracking.Autism research : official journal of the International Society for Autism Research · 2020Trial
- Mediating Parent Learning to Promote Social Communication for Toddlers with Autism: Effects from a Randomized Controlled Trial.Journal of autism and developmental disorders · 2018Trial
- Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years.Journal of child psychology and psychiatry, and allied disciplines · 2017Trial
- Parent-mediated intervention versus no intervention for infants at high risk of autism: a parallel, single-blind, randomised trial.The lancet. Psychiatry · 2015Trial
- Characterizing features of the genetic architecture underlying autism from a multi-ancestry perspective.Molecular psychiatry · 2026Article
- Toward preventive interventions in developmental coordination disorder: in need of early behavioral markers?Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Screening and Prediction of Autism in Toddlers Using SORF in Videos of Brief Family Interactions.Journal of autism and developmental disorders · 2026Article
- Applying artificial intelligence in neurodevelopmental disorders management and research.European journal of medical research · 2026Review
- Prodromal behavioral markers and developmental trajectories of autism spectrum disorder in infancy: a narrative review.Frontiers in pediatrics · 2026Review
- Parental Knowledge, Acceptability, and Involvement in Applied Behavior Analysis for Children with Autism Spectrum Disorder in Jordan: A Cross-Sectional Study.Psychology research and behavior management · 2026Article
- Article
- Parent Use and Perceptions of Problem-Solving Education in the Context of Parent-Implemented Intervention for Toddlers With Early Signs of Autism.Journal of autism and developmental disorders · 2025Article
- A Pilot Evaluation of the PEACE Implementation Toolkit to Improve the Use of Caregiver Coaching in Early Intervention.Behavioral sciences (Basel, Switzerland) · 2025Article
- Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early detection methods for autism spectrum disorder (ASD) in infancy are rapidly advancing, yet the development of interventions for infants under two years with or at-risk for ASD remains limited. In order to guide research and practice, this paper systematically reviewed studies investigating interventions for infants under 24 months with or at-risk for ASD. Nine studies were identified and evaluated for: (a) participants, (b) intervention approach (c) experimental design, and (d) outcomes. Studies that collected parent measures reported positive findings for parent acceptability, satisfaction, and improvement in parent implementation of treatment. Infant gains in social-communicative and developmental skills were observed following intervention in most of the reviewed studies, while comparisons with treatment-as-usual control groups elucidate the need for further research. These studies highlight the feasibility of very early intervention and provide preliminary evidence that intervention for at-risk infants may be beneficial for infants and parents.
Indexed as
Identifiers
25218848What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.