Evidence map›Paper›PMID 25218807›Full record

ArticleNeuroscience2014

Ethanol dose-dependently elicits opposing regulatory effects on hippocampal AMPA receptor GluA2 subunits through a zeta inhibitory peptide-sensitive kinase in adolescent and adult Sprague-Dawley rats.

J L Santerre, J A Rogow, E B Kolitz, R Pal, J D Landin, E D Gigante, D F Werner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

J L SanterreDepartment of Psychology, Center for Development and Behavioral Neuroscience, Binghamton University - State University of New York, Binghamton, NY 13902, USA.
J A RogowDepartment of Psychology, Center for Development and Behavioral Neuroscience, Binghamton University - State University of New York, Binghamton, NY 13902, USA.
E B KolitzDepartment of Psychology, Center for Development and Behavioral Neuroscience, Binghamton University - State University of New York, Binghamton, NY 13902, USA.
R PalDepartment of Psychology, Center for Development and Behavioral Neuroscience, Binghamton University - State University of New York, Binghamton, NY 13902, USA.
J D LandinDepartment of Psychology, Center for Development and Behavioral Neuroscience, Binghamton University - State University of New York, Binghamton, NY 13902, USA.
E D GiganteDepartment of Psychology, Center for Development and Behavioral Neuroscience, Binghamton University - State University of New York, Binghamton, NY 13902, USA.
D F WernerDepartment of Psychology, Center for Development and Behavioral Neuroscience, Binghamton University - State University of New York, Binghamton, NY 13902, USA. Electronic address: dwerner@binghamton.edu.
Binghamton University · US

Funding

Social Anxiety, Stress and Ethanol Sensitivity in Adolescence and AdulthoodP50AA017823 · NIAAA · UPSTATE MEDICAL UNIVERSITY · PI Marvin Rafael Diaz · 2009 to 2026
$30.5M
Faculty recruitment for alcohol researcher, Binghamton UniversityP30AA019367 · NIAAA · STATE UNIVERSITY OF NY,BINGHAMTON · PI SPEAR, LINDA PATIA · 2009 to 2010
$810k
NIAAA NIH HHS AA017823NIAAA NIH HHS AA019367NIAAA NIH HHS P30 AA019367NIAAA NIH HHS P50 AA017823
6 · The paper itself

Abstract

AMPA receptor GluA2 subunits are strongly implicated in cognition, and prior work suggests that these subunits may be regulated by atypical protein kinase C (aPKC) isoforms. The present study assessed whether hippocampal and cortical AMPA receptor GluA2 subunit regulation may be an underlying factor in known age-related differences to cognitive-impairing doses of ethanol, and if aPKC isoforms modulate such responses. Hippocampal AMPA receptor GluA2 subunit, protein kinase Mζ (PKMζ), and PKCι/λ expression were elevated during adolescence compared to adults. 1 h following a low-dose (1.0-g/kg) ethanol exposure, hippocampal AMPA receptor GluA2 subunit serine 880 phosphorylation was decreased in adolescents, but was increased in adults. Age-dependent changes in GluA2 subunit phosphorylation were paralleled by alterations in aPKC isoforms, and zeta inhibitory peptide (ZIP) administration prevented ethanol-induced increases in both in adults. Ethanol-induced changes in GluA2 subunit phosphorylation were associated with delayed regulation in synaptosomal GluA2 subunit expression 24 h later. A higher ethanol dose (3.5-g/kg) failed to elicit changes in most measures in the hippocampus at either age. Similar to the hippocampus, analysis of cerebral cortical tissue also revealed age-related declines. However, no demonstrable effects were found following a low-dose ethanol exposure at either age. High-dose ethanol exposure reduced adolescent GluA2 subunit phosphorylation and aPKC isoform expression that were again accompanied by delayed reductions in synaptosomal GluA2 subunit expression. Together, these results suggest that GluA2-containing AMPA receptor modulation by aPKC isoforms is age-, region- and dose-dependently regulated, and may potentially be involved in developmentally regulated ethanol-induced cognitive impairment and other ethanol behaviors.

Indexed as

AgingAnimalsCentral Nervous System DepressantsCerebral CortexDeath-Associated Protein KinasesDose-Response Relationship, DrugEthanolHippocampusMalePhosphorylationProtein Kinase CProtein Kinase C-deltaRats, Sprague-DawleyReceptors, AMPASynaptosomesCentral Nervous System DepressantsDeath-Associated Protein KinasesEthanolglutamate receptor ionotropic, AMPA 2Protein Kinase CProtein Kinase C-deltaprotein kinase M zeta, ratReceptors, AMPAadolescenceAMPA receptors GluA2 subunitsethanolPKCι/λPKMζprotein kinase C (PKC)

Identifiers

PMID25218807
PMCPMC4482479
OpenAlexW2049638400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.