Evidence map›Paper›PMID 25218561›Full record

ReviewJournal of neuroscience methods2014

Sparse models for correlative and integrative analysis of imaging and genetic data.

Dongdong Lin, Hongbao Cao, Vince D Calhoun, Yu-Ping Wang

Abstract readReview
In one paragraph

Review in Journal of neuroscience methods, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  12. Robust and Discriminative Brain Genome Association Study.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dongdong LinDepartment of Biomedical Engineering, Tulane University, New Orleans, LA, 70118, USA; Center of Genomics and Bioinformatics, Tulane University, New Orleans, LA, 70112, USA. Electronic address: dlin5@tulane.edu.
Hongbao CaoUnit on Statistical Genomics, Intramural Program of Research, National Institute of Mental Health, NIH, Bethesda 20852, USA. Electronic address: hongbao.cao@nih.gov.
Vince D CalhounThe Mind Research Network & LBERI, Albuquerque, NM 87106, USA; Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: vcalhoun@unm.edu.
Yu-Ping WangDepartment of Biomedical Engineering, Tulane University, New Orleans, LA, 70118, USA; Center of Genomics and Bioinformatics, Tulane University, New Orleans, LA, 70112, USA. Electronic address: wyp@tulane.edu.

Funding

Transcranial Direct Current Stimulation for Treatment of Auditory Verbal HalluciP20GM103472 · NIGMS · THE MIND RESEARCH NETWORK · PI ABBOTT, CHRISTOPHER C · 2012 to 2017
$14.3M
Multivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8M
NEURAL MECHANISMS OF SCHIZOPHRENIAP20RR021938 · NCRR · THE MIND RESEARCH NETWORK · PI HANLON, FAITH MARIE · 2008 to 2011
$9.4M
Multi-group semi-blind ICA of fMRIR01EB000840 · NIBIB · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D · 2003 to 2011
$3.2M
Unified multivariate data-driven solutions for static and dynamic brain connectivityR01EB020407 · NIBIB · THE MIND RESEARCH NETWORK · PI ADALI, TULAY, CALHOUN, VINCE D · 2015 to 2018
$2.7M
Integration of brain imaging with genomic and epigenomic dataR01MH104680 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI CALHOUN, VINCE D, DENG, HONG-WEN · 2014 to 2017
$2.1M
Integration of multiscale genomic data for comprehensive analysis of complex diseR01GM109068 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI WANG, YU-PING · 2014 to 2018
$1.6M
NCRR NIH HHS P20 RR021938NIBIB NIH HHS 2R01EB000840NIBIB NIH HHS R01 EB000840NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB020407NIGMS NIH HHS 5P20RR021938/P20GM103472NIGMS NIH HHS P20 GM103472NIGMS NIH HHS R01 GM109068NIGMS NIH HHS R01GM109068NIMH NIH HHS R01 MH104680NIMH NIH HHS R01MH104680
6 · The paper itself

Abstract

The development of advanced medical imaging technologies and high-throughput genomic measurements has enhanced our ability to understand their interplay as well as their relationship with human behavior by integrating these two types of datasets. However, the high dimensionality and heterogeneity of these datasets presents a challenge to conventional statistical methods; there is a high demand for the development of both correlative and integrative analysis approaches. Here, we review our recent work on developing sparse representation based approaches to address this challenge. We show how sparse models are applied to the correlation and integration of imaging and genetic data for biomarker identification. We present examples on how these approaches are used for the detection of risk genes and classification of complex diseases such as schizophrenia. Finally, we discuss future directions on the integration of multiple imaging and genomic datasets including their interactions such as epistasis.

Indexed as

Databases, GeneticDiagnostic ImagingGenomicsModels, GeneticAnimalsBrainHumansModels, StatisticalPrincipal Component AnalysisClassificationCorrespondence analysisImaging geneticsIntegrationSparse modeling

Identifiers

PMID25218561
PMCPMC4194220

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.