ReviewTrends in neurosciences2014
Axon plasticity in the mammalian central nervous system after injury.
Review in Trends in neurosciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Early interventions to prevent lower urinary tract dysfunction after spinal cord injury: a systematic review.Spinal cord · 2022Pooled it
- Impaired axon regeneration and heightened synaptic dynamics in the injured aged mammalian cortex.iScience · 2025Article
- Review
- Hallmarks of Brain Plasticity.Biomedicines · 2025Review
- Lentivirus-mediated Knockdown of Ski Improves Neurological Function After Spinal Cord Injury in Rats.Neurochemical research · 2024Article
- Advance in pediatric spinal cord injury.Pediatric discovery · 2024Review
- Changes in the dopaminergic circuitry and adult neurogenesis linked to reinforcement learning in corvids.Frontiers in neuroscience · 2024Article
- Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery.Neuroscience bulletin · 2022Review
- LZK-dependent stimulation of astrocyte reactivity promotes corticospinal axon sprouting.Frontiers in cellular neuroscience · 2022Article
- Capacity of astrocytes to promote axon growth in the injured mammalian central nervous system.Frontiers in neuroscience · 2022Review
- Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier.Cells · 2021Review
- Co-occupancy identifies transcription factor co-operation for axon growth.Nature communications · 2021Article
- Dual Oxidase Mutant Retards Mauthner-Cell Axon Regeneration at an Early Stage via Modulating Mitochondrial Dynamics in Zebrafish.Neuroscience bulletin · 2020Article
- Functional Electrical Stimulation and the Modulation of the Axon Regeneration Program.Frontiers in cell and developmental biology · 2020Review
- Post-stroke remodeling processes in animal models and humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Review
- Magnetic Field Promotes Migration of Schwann Cells with Chondroitinase ABC (ChABC)-Loaded Superparamagnetic Nanoparticles Across Astrocyte Boundary in vitro.International journal of nanomedicine · 2020Article
- Review
- Article
- Neuropilin-1-mediated pruning of corticospinal tract fibers is required for motor recovery after spinal cord injury.Cell death & disease · 2019Article
- The Role of Apoptotic Signaling in Axon Guidance.Journal of developmental biology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
It is widely recognized that severed axons in the adult central nervous system (CNS) have limited capacity to regenerate. However, mounting evidence from studies of CNS injury response and repair is challenging the prevalent view that the adult mammalian CNS is incapable of structural reorganization to adapt to an altered environment. Animal studies demonstrate the potential to achieve significant anatomical repair and functional recovery following CNS injury by manipulating axon growth regulators alone or in combination with activity-dependent strategies. With a growing understanding of the cellular and molecular mechanisms regulating axon plasticity, and the availability of new experimental tools to map detour circuits of functional importance, directing circuit rewiring to promote functional recovery may be achieved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.