Evidence map›Paper›PMID 25218438›Full record

ArticleGlycoconjugate journal2014

Compositional analysis and structural elucidation of glycosaminoglycans in chicken eggs.

Zhangguo Liu, Fuming Zhang, Lingyun Li, Guoyun Li, Wenqing He, Robert J Linhardt

Open access · greenAbstract read
In one paragraph

Article in Glycoconjugate journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. A comparison of several separation processes for eggshell membrane powder as a natural biomaterial for skin regeneration.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Methods for isolating and analyzing physiological hyaluronan: a review.American journal of physiology. Cell physiology · 2022
    Review
  11. Review
  12. Recent Advances in Applications of Bioactive Egg Compounds in Nonfood Sectors.Frontiers in bioengineering and biotechnology · 2021
    Review
  13. Article
  14. Glycosaminoglycans from Co-Products of «Biological procedures online · 2020
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Zhangguo LiuCollege of Animal Science, Zhejiang Agriculture & Forestry University, Lin'an, Zhejiang, 311300, China.
Fuming Zhang
Lingyun Li
Guoyun Li
Wenqing He
Robert J Linhardt
Rensselaer Polytechnic Institute · USZhejiang A & F University · CN

Funding

In vitro synthesis of recombinant heparan sulfateR01HL094463 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, JIAN, PAWLINSKI, RAFAL L · 2009 to 2021
$5.2M
Synthetic Heparan Sulfate: Probing Biosynthesis to Prepare Defined DrugsR01HL062244 · NHLBI · UNIVERSITY OF IOWA · PI DEANGELIS, PAUL L, LINHARDT, ROBERT J · 2001 to 2016
$4.1M
Development of a Bioengineered Heparin from a Non-Animal SourceR01HL096972 · NHLBI · RENSSELAER POLYTECHNIC INSTITUTE · PI DORDICK, JONATHAN S., LINHARDT, ROBERT J · 2009 to 2013
$3.9M
Characterization of Anticoagulant Heparin and Related PolysaccharidesRC2HL101721 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LINHARDT, ROBERT J, SASISEKHARAN, RAM · 2009 to 2010
$1.3M
Uncovering the controlling mechanisms in heparan sulfate biosynthesisU01GM102137 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, JIAN · 2013 to 2016
$1.2M
NHLBI NIH HHS HL094463NHLBI NIH HHS HL096972NHLBI NIH HHS HL62244NHLBI NIH HHS R01 HL062244NHLBI NIH HHS R01 HL094463NHLBI NIH HHS R01 HL096972NHLBI NIH HHS RC2 HL101721NIGMS NIH HHS GM102137NIGMS NIH HHS U01 GM102137
6 · The paper itself

Abstract

Glycosaminoglycans (GAGs) have numerous applications in the fields of pharmaceuticals, cosmetics, nutraceuticals, and foods. GAGs are also critically important in the developmental biology of all multicellular animals. GAGs were isolated from chicken egg components including yolk, thick egg white, thin egg white, membrane, calcified shell matrix supernatant, and shell matrix deposit. Disaccharide compositional analysis was performed using ultra high-performance liquid chromatography-mass spectrometry. The results of these analyses showed that all four families of GAGs were detected in all egg components. Keratan sulfate was found in egg whites (thick and thin) and shell matrix (calcified shell matrix supernatant and deposit) with high level. Chondroitin sulfates were much more plentiful in both shell matrix components and membrane. Hyaluronan was plentiful in both shell matrix components and membrane, but was only present in a trace of quantities in the yolk. Heparan sulfate was plentiful in the shell matrix deposit but was present in a trace of quantities in the egg content components (yolk, thick and thin egg whites). Most of the chondroitin and heparan sulfate disaccharides were present in the GAGs found in chicken eggs with the exception of chondroitin and heparan sulfate 2,6-disulfated disaccharides. Both CS and HS in the shell matrix deposit contained the most diverse chondroitin and heparan sulfate disaccharide compositions. Eggs might provide a potential new source of GAGs.

Indexed as

AnimalsAzetidinesChickensChondroitin SulfatesDermatan SulfateDisaccharidesGlycosaminoglycansHyaluronic AcidKeratan SulfateNitrilesOvum1-(2-amino-3-methyl-butyryl)-azetidine-2-carbonitrileAzetidinesChondroitin SulfatesDermatan SulfateDisaccharidesGlycosaminoglycansHyaluronic AcidKeratan SulfateNitriles

Identifiers

PMID25218438
PMCPMC4229509
OpenAlexW2119868405

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.