The effect of tracheal occlusion on respiratory load compensation: changes in neurons containing inhibitory neurotransmitter in the nucleus of the solitary tract in conscious rats.

Hsiu-Wen Tsai, Jillian Condrey, Sherry Adams, Paul W Davenport

Abstract read

In one paragraph

Article in Respiratory physiology & neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 58% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hsiu-Wen TsaiDepartment of Physiological Sciences, University of Florida, Gainesville, United States.

Jillian CondreyDepartment of Physiological Sciences, University of Florida, Gainesville, United States.

Sherry AdamsDepartment of Physiological Sciences, University of Florida, Gainesville, United States.

Paul W DavenportDepartment of Physiological Sciences, University of Florida, Gainesville, United States. Electronic address: davenportp@ufl.edu.

University of Florida · US

Funding

Mechanisms of Swallow Control of BreathingR01HL109025 · NHLBI · UNIVERSITY OF FLORIDA · PI DAVENPORT, PAUL W, MORRIS, KENDALL FRANCIS · 2012 to 2015

$2.9M

NHLBI NIH HHS HL109025NHLBI NIH HHS R01 HL109025

6 · The paper itself

Abstract

Respiratory load compensation volume-time (Vt-T) relationships have been extensively studied in anesthetized animals. There are only a few studies in conscious animals although consciousness and behavior play a critical role in modulation of breathing. The aims of the study were to determine the effect of intermittent and transient tracheal occlusions (ITTO) elicited load compensation responses and the changes in activation of inhibitory glycinergic neurons in the nucleus of solitary tract (NTS) in conscious rats. The results showed that ITTO elicited an increase in expiratory time (T(e)) but did not affect inspiratory time (T(i)) and diaphragm activity (EMG(dia)). An increase in total breathing time (Ttot) was due exclusively to the increase in T(e). In addition, glycinergic neurons were activated in the intermediate NTS (iNTS) but not in the caudal NTS (cNTS). These results suggest that the activated glycinergic neurons in the iNTS may be important for the neurogenesis of load compensation responses in conscious animals.

Indexed as

RespirationAirway ObstructionAnimalsConsciousnessDiaphragmDisease Models, AnimalElectromyographyFluorescent Antibody TechniqueGlycineGlycine Plasma Membrane Transport ProteinsMaleNeural InhibitionNeuronsProto-Oncogene Proteins c-fosRandom AllocationRats, Sprague-DawleyGlycineGlycine Plasma Membrane Transport ProteinsProto-Oncogene Proteins c-fosSlc6a5 protein, ratGlycinergic neuronInhibitor neurotransmitterLoad compensationNTSTreacheal occlusion

Identifiers

PMID25218413

DOI10.1016/j.resp.2014.09.002

PMCPMC5575808

OpenAlexW1992966046

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.