Evidence map›Paper›PMID 25218271›Full record

ArticleMedical oncology (Northwood, London, England)2014

MicroRNA-106b~25 expressions in tumor tissues and plasma of patients with gastric cancers.

Rupeng Zhang, Weijia Wang, Fangxuan Li, Hui Zhang, Juntian Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
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  10. microRNA-3129 promotes cell proliferation in gastric cancer cell line SGC7901 via positive regulation of pRb.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018
    Article
  11. Article
  12. Article
  13. Article
  14. The effect of antisense inhibitor of miRNA 106b∼25 on the proliferation, invasion, migration, and apoptosis of gastric cancer cell.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  15. Review
  16. Article
  17. New Concepts in Cancer Biomarkers: Circulating miRNAs in Liquid Biopsies.International journal of molecular sciences · 2016
    Review
  18. Article
  19. Dysregulation of non-coding RNAs in gastric cancer.World journal of gastroenterology · 2015
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Rupeng ZhangDepartment of Gastric Cancer Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Weijia Wang
Fangxuan Li
Hui Zhang
Juntian Liu
Tianjin Medical University Cancer Institute and Hospital · CNNational Clinical Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MiR-106b~25 has been researched in several cancers. The aim of this study was to test miR-106b~25 expressions in 40 operative specimens and 20 pre-operative plasma samples of GC patients and explore the correlations between these miRNAs and some related clinical pathological factors. Compared with corresponding adjacent non-tumorous tissues, the expression of miR-106b~25 cluster increased significantly in gastric cancer tissues from 40 samples, with a median relative expression of 2.41(miR-106b), 2.83(miR-93) and 2.71(miR-25). The expression of miRNA-106b~25 cluster in tumor tissues was significantly correlated with tumor size, borrmann type, depth of tumor invasion (T), lymph node metastases (N), distant metastasis (M) and TNM stage (P<0.05). The expressive level of miRNA-106b~25 cluster was also statistically significant higher than healthy volunteers in plasma, with a median of 2.51(miR-106b), 2.32(miR-93) and 2.10(miR-25). The expression of miR-106b~25 cluster in plasma was significantly correlated with tumor size, borrmann type and TNM stage (P<0.05) in GC patients. What's more, the three components of miR-106b~25 cluster expressed consistently at a high level both in specimens and plasma. Considering the relationship between three miRNAs and some clinical pathological factors (TNM stage), it was implied that miR-106b~25 could be the next potential tumor biomarker for diagnosis and predictive prognosis for gastric cancer patients.

Indexed as

AdultAgedBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHealthy VolunteersHumansLymphatic MetastasisMaleMicroRNAsMiddle AgedReal-Time Polymerase Chain ReactionStomach NeoplasmsBiomarkers, TumorMicroRNAsMIRN106 microRNA, human

Identifiers

PMID25218271
OpenAlexW2089028593

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.