Evidence map›Paper›PMID 25217961›Full record

SynthesisNature genetics2014

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.

Ali Amin Al Olama, Zsofia Kote-Jarai, Sonja I Berndt, David V Conti, Fredrick Schumacher, Ying Han, Sara Benlloch, Dennis J Hazelett, Zhaoming Wang, Ed Saunders and 158 more

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03805919 (Natural History Study of Men at High Genetic Risk for Prostate Cancer), which is not on this map. Cited by 281 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
281citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03805919 recruitingnot on this mapstarted 2019, after this paper: background citation

Natural History Study of Men at High Genetic Risk for Prostate Cancer

TypeobservationalSponsorNational Cancer Institute (NCI)Ran2019 to 2039Enrolled500ConditionsProstatic Neoplasms
3 · Its place in the literature

Who cites it

281 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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221 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

168 authors.

Ali Amin Al Olama1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [2].
Zsofia Kote-Jarai1] Institute of Cancer Research, London, UK. [2].
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
David V Conti1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Fredrick Schumacher1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Ying HanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Sara BenllochCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Dennis J Hazelett1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Zhaoming Wang1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick, Maryland, USA.
Ed SaundersInstitute of Cancer Research, London, UK.
Daniel LeongamornlertInstitute of Cancer Research, London, UK.ORCID 0000000234863168
Sara LindstromProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
Sara Jugurnauth-LittleInstitute of Cancer Research, London, UK.
Tokhir DadaevInstitute of Cancer Research, London, UK.ORCID 0000000282680438
Malgorzata TymrakiewiczInstitute of Cancer Research, London, UK.
Daniel O Stram1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Kristin RandDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Peggy WanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Alex StramDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Xin ShengDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Loreall C PoolerDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Karen ParkDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Lucy XiaDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jonathan TyrerCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Laurence N KolonelEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Robert N HooverDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
Merideth YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
Laurie BurdetteDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
Charles C ChungDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
Amy HutchinsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
Kai YuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
Chee GohInstitute of Cancer Research, London, UK.
Mahbubl AhmedInstitute of Cancer Research, London, UK.
Koveela GovindasamiInstitute of Cancer Research, London, UK.
Michelle GuyInstitute of Cancer Research, London, UK.
Teuvo L J TammelaDepartment of Urology, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland.
Anssi AuvinenDepartment of Epidemiology, School of Health Sciences, University of Tampere, Tampere, Finland.
Tiina WahlforsBioMediTech, University of Tampere and FimLab Laboratories, Tampere, Finland.
Johanna Schleutker1] BioMediTech, University of Tampere and FimLab Laboratories, Tampere, Finland. [2] Department of Medical Biochemistry, Institute of Biomedicine, University of Turku, Turku, Finland.ORCID 0000000218630305
Tapio VisakorpiInstitute of Biomedical Technology/BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland.
Katri A LeinonenInstitute of Biomedical Technology/BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland.
Jianfeng XuCenter for Cancer Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Markus Aly1] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. [2] Department of Clinical Sciences at Danderyds Hospital, Stockholm, Sweden.
Jenny DonovanSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Tim J KeyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Afshan SiddiqDepartment of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kay-Tee KhawClinical Gerontology Unit, University of Cambridge, Cambridge, UK.
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Michiaki KuboLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Paul PharoahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Nora PashayanCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Maren WeischerDepartment of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.
Borge G Nordestgaard1] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark. [2] Faculty of Healthy and Medical Sciences, University of Copenhagen, Herlev, Denmark.
Sune F Nielsen1] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark. [2] Faculty of Healthy and Medical Sciences, University of Copenhagen, Herlev, Denmark.
Peter KlarskovDepartment of Urology, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.
Martin Andreas RøderCopenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.ORCID 0000000200195333
Peter IversenCopenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Stephen N ThibodeauMayo Clinic, Rochester, Minnesota, USA.
Shannon K McDonnellMayo Clinic, Rochester, Minnesota, USA.
Daniel J SchaidMayo Clinic, Rochester, Minnesota, USA.
Janet L Stanford1] Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [2] Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
Suzanne KolbDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Sarah HoltFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Beatrice KnudsenTranslational Pathology, Cedars-Sinai, Los Angeles, California, USA.
Antonio Hurtado CollProstate Center, Vancouver, British Columbia, Canada.
Susan M GapsturEpidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
W Ryan DiverEpidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.ORCID 0000000254189000
Victoria L StevensEpidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
Christiane MaierDepartment of Urology, University Hospital Ulm, Ulm, Germany.
Manuel LuedekeDepartment of Urology, University Hospital Ulm, Ulm, Germany.
Kathleen HerkommerDepartment of Urology, Klinikum Rechts der Isar der Technischen Universität München, Munich, Germany.
Antje E RincklebDepartment of Urology, University Hospital Ulm, Ulm, Germany.
Sara S StromDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Curtis PettawayDepartment of Urology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Edward D Yeboah1] University of Ghana Medical School, Accra, Ghana. [2] Korle Bu Teaching Hospital, Accra, Ghana.
Yao Tettey1] University of Ghana Medical School, Accra, Ghana. [2] Korle Bu Teaching Hospital, Accra, Ghana.
Richard B Biritwum1] University of Ghana Medical School, Accra, Ghana. [2] Korle Bu Teaching Hospital, Accra, Ghana.
Andrew A Adjei1] University of Ghana Medical School, Accra, Ghana. [2] Korle Bu Teaching Hospital, Accra, Ghana.
Evelyn Tay1] University of Ghana Medical School, Accra, Ghana. [2] Korle Bu Teaching Hospital, Accra, Ghana.
Ann TrueloveWestat, Rockville, Maryland, USA.
Shelley NiwaWestat, Rockville, Maryland, USA.
Anand P ChokkalingamSchool of Public Health, University of California, Berkeley, Berkeley, California, USA.
Lisa Cannon-Albright1] Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA. [2] George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah, USA.
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Dominika WokołorczykInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Wojciech KluźniakInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jong ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Thomas SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Hui-Yi LinDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, USA.
William B IsaacsJames Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, Maryland, USA.
Alan W PartinJames Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, Maryland, USA.
Hermann Brenner1] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] German Cancer Consortium, Heidelberg, Germany.
Aida Karina Dieffenbach1] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] German Cancer Consortium, Heidelberg, Germany.
Christa StegmaierSaarland Cancer Registry, Saarbrücken, Germany.
Constance ChenProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
Edward L Giovannucci1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Jing MaChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Meir Stampfer1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. [3] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Kathryn L Penney1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Lorelei Mucci1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Esther M John1] Cancer Prevention Institute of California, Fremont, California, USA. [2] Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA.
Sue A Ingles1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Rick A KittlesDepartment of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
Adam B MurphyDepartment of Urology, Northwestern University, Chicago, Illinois, USA.
Hardev PandhaFaculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Agnieszka MichaelFaculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Andrzej M KierzekFaculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
William Blot1] International Epidemiology Institute, Rockville, Maryland, USA. [2] Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Lisa B Signorello1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Demetrius AlbanesNutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
Jarmo VirtamoDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Stephanie WeinsteinNutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
Barbara NemesureDepartment of Preventive Medicine, Stony Brook University, Stony Brook, New York, USA.
John CarptenTranslational Genomics Research Institute, Phoenix, Arizona, USA.
Cristina LeskeDepartment of Preventive Medicine, Stony Brook University, Stony Brook, New York, USA.
Suh-Yuh WuDepartment of Preventive Medicine, Stony Brook University, Stony Brook, New York, USA.
Anselm Hennis1] Department of Preventive Medicine, Stony Brook University, Stony Brook, New York, USA. [2] Chronic Disease Research Centre, University of the West Indies, Bridgetown, Barbados.
Adam S KibelDivision of Urologic Surgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Benjamin A RybickiDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan, USA.
Christine Neslund-DudasDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan, USA.
Ann W Hsing1] Cancer Prevention Institute of California, Fremont, California, USA. [2] Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA.
Lisa Chu1] Cancer Prevention Institute of California, Fremont, California, USA. [2] Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA.
Phyllis J GoodmanSouthwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Eric A KleinDepartment of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.
S Lilly ZhengCenter for Cancer Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Jyotsna BatraAustralian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Translational Research Institute, Brisbane, Queensland, Australia.
Judith ClementsAustralian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Translational Research Institute, Brisbane, Queensland, Australia.
Amanda SpurdleMolecular Cancer Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Manuel R Teixeira1] Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. [2] Biomedical Sciences Institute, University of Porto, Porto, Portugal.
Paula PauloDepartment of Genetics, Portuguese Oncology Institute, Porto, Portugal.
Sofia MaiaDepartment of Genetics, Portuguese Oncology Institute, Porto, Portugal.
Chavdar SlavovDepartment of Urology, Medical University-Sofia, Sofia, Bulgaria.
Radka KanevaDepartment of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University-Sofia, Sofia, Bulgaria.
Vanio MitevDepartment of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University-Sofia, Sofia, Bulgaria.
John S Witte1] Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA. [2] Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Graham Casey1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Elizabeth M GillandersDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA.
Daniella SeminaraDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA.
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Freddie C HamdyNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Gerhard A Coetzee1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Qiyuan LiDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Matthew L FreedmanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
David J HunterProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
Kenneth Muir1] Institute of Population Health, University of Manchester, Manchester, UK. [2] Warwick Medical School, University of Warwick, Coventry, UK.
Henrik GronbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
David E Neal1] Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK. [2] Department of Oncology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Melissa SoutheyGenetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.
Graham G Giles1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Gianluca Severi1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia. [3] Human Genetics Foundation, Torino, Italy.
Breast and Prostate Cancer Cohort Consortium (BPC3)
PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
COGS (Collaborative Oncological Gene-environment Study) Consortium
GAME-ON/ELLIPSE Consortium
Michael B Cook1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA. [2].
Hidewaki Nakagawa1] Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan. [2].
Fredrik Wiklund1] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. [2].
Peter Kraft1] Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA. [3].
Stephen J Chanock1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA. [2].
Brian E Henderson1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA. [3].
Douglas F Easton1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [2].
Rosalind A Eeles1] Institute of Cancer Research, London, UK. [2] Royal Marsden National Health Service (NHS) Foundation Trust, London and Sutton, UK. [3].
Christopher A Haiman1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA. [3].

Funding

SWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2M
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Prostate Cancer Susceptibility: The ICPCG StudyU01CA089600 · NCI · MAYO CLINIC ROCHESTER · PI THIBODEAU, STEPHEN NORMAN · 2002 to 2016
$27.3M
Targeting Tumor Microenvironment-Induced Therapy Resistance in Prostate Cancer Bone MetastasisP50CA140388 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LOGOTHETIS, CHRISTOPHER J., THOMPSON, TIMOTHY CHARLES · 2009 to 2022
$23.4M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Pilot Project ProgramP30ES007784 · NIEHS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI RICHIE, ELLEN R · 1996 to 2011
$16.4M
The Howard University SCORE Program Supplemental GrantS06GM008016 · NIGMS · HOWARD UNIVERSITY · PI NELSON, KAREN ELIZABETH · 1989 to 2009
$16.1M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098758 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2003 to 2010
$11.0M
Cancer Research UK 10118Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 11022Cancer Research UK 13065Cancer Research UK 14136Cancer Research UK 15007Cancer Research UK 16491Cancer Research UK 16561Cancer Research UK 16563Cancer Research UK 17528Medical Research Council G0401527Medical Research Council G0900871Medical Research Council G1000143NCI NIH HHS P30 CA042014NCI NIH HHS P30 CA068485NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA140388NCI NIH HHS R01 CA056678NCI NIH HHS R01 CA068578NCI NIH HHS R01 CA072818NCI NIH HHS R01 CA082664NCI NIH HHS R01 CA084979NCI NIH HHS R01 CA088164NCI NIH HHS R01 CA092447NCI NIH HHS R01 CA092579NCI NIH HHS R01 CA128813NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA136924NCI NIH HHS R37 CA054281NCI NIH HHS RC2 CA148085NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA089600NCI NIH HHS U01 CA098216NCI NIH HHS U01 CA098233NCI NIH HHS U01 CA098710NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA127298NCI NIH HHS U01 CA136792NCI NIH HHS U10 CA037429NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UG1 CA189974NCI NIH HHS UM1 CA182883NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG004726NIEHS NIH HHS P30 ES007784NIEHS NIH HHS R01 ES011126NIGMS NIH HHS P01 GM099568NIGMS NIH HHS S06 GM008016Prostate Cancer UK G2011/36Prostate Cancer UK G2012/48
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

Indexed as

Polymorphism, Single NucleotideGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleProstatic NeoplasmsRisk AssessmentRisk Factors

Identifiers

PMID25217961
PMCPMC4383163

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