Evidence map›Paper›PMID 25217871›Full record

ArticleFertility and sterility2014

Using the Society for Assisted Reproductive Technology Clinic Outcome System morphological measures to predict live birth after assisted reproductive technology.

Barbara Luke, Morton B Brown, Judy E Stern, Sangita K Jindal, Catherine Racowsky, G David Ball

Abstract readValidation Study
In one paragraph

Article in Fertility and sterility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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  13. Association between Number of Formed Embryos, Embryo Morphology and Clinical Pregnancy Rate after Intracytoplasmic Sperm Injection.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Barbara LukeDepartment of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, Michigan. Electronic address: lukeb@msu.edu.
Morton B BrownDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan.
Judy E SternDepartment of Obstetrics and Gynecology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Sangita K JindalMontefiore's Institute for Reproductive Medicine and Health, Albert Einstein College of Medicine, Hartsdale, New York.
Catherine RacowskyDepartment of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts.
G David BallSeattle Reproductive Medicine, Seattle, Washington.

Funding

Assisted Reproductive Technology & Risk of Childhood CancerR01CA151973 · NCI · MICHIGAN STATE UNIVERSITY · PI LUKE, BARBARA JOAN, SPECTOR, LOGAN G. · 2011 to 2015
$3.0M
NCI NIH HHS R01 CA151973NCI NIH HHS R01CA51973
6 · The paper itself

Abstract

objectiveTo model morphological assessments of embryo quality that are predictive of live birth.

designLongitudinal cohort using cycles reported in the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System (SART CORS) between 2007 and 2011.

settingClinic-based data. PATIENT(S): Fresh autologous assisted reproductive technology (ART) cycles with ETs on day 3 or day 5 and morphological assessments reported (25,409 cycles with one embryo transferred and 96,093 cycles with two embryos transferred). Live-birth rates were modeled by morphological assessments using backward-stepping logistic regression for cycle 1 and over five cycles, separately for day 3 and day 5 transfers and number of embryos transferred (1 or 2). Additional models for each day of transfer also included the number of oocytes retrieved and the number of embryos cryopreserved. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live births. RESULT(S): Morphological assessments of grade, stage, fragmentation, and symmetry were significant for the day 3 models; grade, stage, and trophectoderm were significant in the day 5 model; inner-cell mass was significant in the models when two embryos were transferred. Number of oocytes retrieved and number of embryos cryopreserved were significant for both day 3 and day 5 models. CONCLUSION(S): These findings confirm the significant association between embryo quality parameters reported to SART CORS and live-birth rate after ART.

Indexed as

Models, StatisticalAdultAgedComputer SimulationEmbryo, MammalianEmbryo TransferFemaleHumansIncidenceInfertility, FemaleLive BirthLongitudinal StudiesMiddle AgedOutcome Assessment, Health CarePregnancyPrognosisembryo fragmentationEmbryo morphologyembryo symmetrylive birth ratetrophoblast

Identifiers

PMID25217871
PMCPMC4252875

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.