ReviewJournal of bioenergetics and biomembranes2015
Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection.
Review in Journal of bioenergetics and biomembranes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Effects of Voluntary Running Wheel Activity and Hypertension on the Brain of Female Spontaneously Hypertensive Rats (SHRs).International journal of molecular sciences · 2026Article
- Attention-deficit hyperactivity disorder in spontaneously hypertensive rat strain SHR/NCrl is associated with specific expression of uncoupling proteins, glucose transporter 1 and BACE1.Frontiers in cellular neuroscience · 2025Article
- Photothermal Effects of High-Energy Photobiomodulation Therapies: An In Vitro Investigation.Biomedicines · 2023Article
- The effect of NrfBMC cancer · 2022Article
- Uncoupling Proteins as Therapeutic Targets for Neurodegenerative Diseases.International journal of molecular sciences · 2022Review
- Translation, ribosome biogenesis, and oxidative damage caused by chlorpyrifos exposure to common carp (Cyprinus carpio L.) liver: application of combined RNA-seq with sRNA-seq in risk evaluation of environmental toxicant chlorpyrifos.Environmental science and pollution research international · 2021Article
- miR-129-3p Targeting of MCU Protects Against Glucose Fluctuation-Mediated Neuronal Damage via a Mitochondrial-Dependent Intrinsic Apoptotic Pathway.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications.Redox biology · 2020Review
- Diabetes as a risk factor for Alzheimer's disease in the Middle East and its shared pathological mediators.Saudi journal of biological sciences · 2020Review
- Molecular Mechanisms of Glucose Fluctuations on Diabetic Complications.Frontiers in endocrinology · 2019Review
- PEDF protects human retinal pigment epithelial cells against oxidative stress via upregulation of UCP2 expression.Molecular medicine reports · 2019Article
- Uncoupling protein 4 (Aging · 2018Article
- Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects.Neurotoxicity research · 2018Article
- Sweet Mitochondria: A Shortcut to Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2018Review
- Melatonin, clock genes and mitochondria in sepsis.Cellular and molecular life sciences : CMLS · 2017Review
- Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults.PloS one · 2017Article
- Neuroprotective Properties ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- UCP-2 is involved in angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice.PloS one · 2017Article
- The Crosstalk between ROS and Autophagy in the Field of Transplantation Medicine.Oxidative medicine and cellular longevity · 2017Review
- Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration.Frontiers in cellular neuroscience · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integrity of mitochondrial function is essential to cell life. It follows that disturbances of mitochondrial function will lead to disruption of cell function, expressed as disease or even death. Considering that neuronal uncoupling proteins (UCPs) decrease reactive oxygen species (ROS) production at the expense of energy production, it is important to understand the underlying mechanisms by which UCPs control the balance between the production of adenosine triphosphate (ATP) and ROS in the context of normal physiological activity and in pathological conditions. Here we review the current understanding of neuronal UCPs-mediated respiratory uncoupling process by performing a survey in their physiology and regulation. The latest findings regarding neuronal UCPs physiological roles and their involvement and interest as potential targets for therapeutic intervention in brain diseases will also be exploited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.