ReviewPediatric surgery international2014
The great divide: septation and malformation of the cloaca, and its implications for surgeons.
Review in Pediatric surgery international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Pediatric incidental appendectomy: a systematic review.Pediatric surgery international · 2016Pooled it
- Spatiotemporal remodelling of the cloacal region determines the position of the anal opening in mouse embryos.Journal of anatomy · 2026Article
- Management and Outcomes of Anorectal Malformations at University Teaching Hospital of Kigali, Rwanda from 2015 to 2023.Research square · 2025Article
- The role of ultrasonography in detecting and classifying anorectal malformations in neonates: a retrospective study of 30 cases.Pediatric surgery international · 2025Article
- Differentiation of human pluripotent stem cells into urothelial organoids via transient activation of WNT signaling.iScience · 2025Article
- Impact of Endocrine Disruptors on the Genitourinary Tract.Journal of xenobiotics · 2024Review
- Anorectal malformations.Nature reviews. Disease primers · 2024Review
- Host-derived protein profiles of human neonatal meconium across gestational ages.Nature communications · 2024Article
- Cloacal Dysgenesis Sequence in a Preterm Neonate.The American journal of case reports · 2024Article
- Novel autopsy and genetic findings in an acardiac twin: case report and literature review.Autopsy & case reports · 2024Article
- Prenatal detection of chromosomal abnormalities and copy number variants in fetuses with congenital gastrointestinal obstruction.BMC pregnancy and childbirth · 2022Article
- Progenitors in prostate development and disease.Developmental biology · 2021Review
- The spectrum of cloacal malformations: how to differentiate each entity prenatally with fetal MRI.Pediatric radiology · 2019Review
- Persistent cloaca and caudal duplication in a monovular twin, a rare case report.International journal of surgery case reports · 2019Article
- Systematic stereoscopic analyses for cloacal development: The origin of anorectal malformations.Scientific reports · 2015Article
- Temporal, spatial, and genetic regulation of external genitalia development.Differentiation; research in biological diversityReview
- Cloacal Malformation in Female Children: Outcome of Initial Management.Pakistan journal of medical sciencesArticle
- Imperforate Anus with Jejunal Atresia Complicated by Intestinal Volvulus: A Case Report.Journal of neonatal surgeryArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The anorectal and urogenital systems arise from a common embryonic structure termed cloaca. Subsequent development leads to the division/septation of the cloaca into the urethra, urinary bladder, vagina, anal canal, and rectum. Defective cloacal development and the resulting anorectal and urogenital malformations are some of the most severe congenital anomalies encountered in children. In the most severe form in females, the rectum, vagina, and urethra fail to develop separately and drain via a single common channel known as a cloaca into the perineum. In this review, we summarize our current knowledge of embryonic cloaca development and malformation, and compare them to what has already been described in the literature. We describe the use of mouse models of cloaca malformation to understand which signaling pathways and cellular mechanisms are involved in the process of normal cloaca development. We also discuss the embryological correlation of the epithelial and stromal histology found in step sections of the common channel in 14 human cloaca malformations. Finally, we highlight the significance of these findings, compare them to prior studies, and discuss their implications for the pediatric surgeons. Understanding and identifying the molecular basis for cloaca malformation could provide foundation for tissue engineering efforts that in the future would reflect better surgical reconstruction and improved quality of life for patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.