ArticleNucleic acids research2014
The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Biochemical and structural basis of Dicer helicase function unveiled by resurrecting ancient proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Regulation and mechanisms of action of RNA helicases.RNA biology · 2024Review
- Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism.Nucleic acids research · 2023Article
- Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1.Nature structural & molecular biology · 2023Article
- Structural Insights into the Advances and Mechanistic Understanding of Human Dicer.Biochemistry · 2023Review
- The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands.Molecular cell · 2022Article
- The molecular mechanism of RIG-I activation and signaling.Immunological reviews · 2021Review
- ATP Hydrolysis by the SNF2 Domain of Dnmt5 Is Coupled to Both Specific Recognition and Modification of Hemimethylated DNA.Molecular cell · 2020Article
- RNA binding activates RIG-I by releasing an autorepressed signaling domain.Science advances · 2019Article
- The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans.Viruses · 2019Review
- Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.Molecular cell · 2018Article
- HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity.Nature communications · 2018Article
- A minimal RNA ligand for potent RIG-I activation in living mice.Science advances · 2018Article
- When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins.Current opinion in structural biology · 2016Review
- The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selection.Nucleic acids research · 2016Article
- Article
- Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5.BMC biology · 2015Article
- OASes and STING: adaptive evolution in concert.Genome biology and evolution · 2015Article
- Sensing viral RNAs by Dicer/RIG-I like ATPases across species.Current opinion in immunology · 2015Review
- Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor expressed in metazoan cells that is responsible for eliciting the production of type I interferons and pro-inflammatory cytokines upon detection of intracellular, non-self RNA. Structural studies of RIG-I have identified a novel Pincer domain composed of two alpha helices that physically tethers the C-terminal domain to the SF2 helicase core. We find that the Pincer plays an important role in mediating the enzymatic and signaling activities of RIG-I. We identify a series of mutations that additively decouple the Pincer motif from the ATPase core and show that this decoupling results in impaired signaling. Through enzymological and biophysical analysis, we further show that the Pincer domain controls coupled enzymatic activity of the protein through allosteric control of the ATPase core. Further, we show that select regions of the HEL1 domain have evolved to potentiate interactions with the Pincer domain, resulting in an adapted ATPase cleft that is now responsive to adjacent domains that selectively bind viral RNA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.