ArticleCerebral cortex (New York, N.Y. : 1991)2015
Structural Connectivity Networks of Transgender People.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02715232 (Effects of Sex Steroid Hormones on Serotonin Synthesis and Degradation Measured With PET), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Sex Steroid Hormones on Serotonin Synthesis and Degradation Measured With PET
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of the neural correlates of sexual minority stress: towards an intersectional minority mosaic framework with implications for a future research agenda.European journal of psychotraumatology · 2022Pooled it
- Structural, Functional, and Metabolic Brain Differences as a Function of Gender Identity or Sexual Orientation: A Systematic Review of the Human Neuroimaging Literature.Archives of sexual behavior · 2021Pooled it
- Sex versus Gender Role Endorsement Associations With White Matter Microstructure in South African Adults: A Diffusion Tensor Imaging Study.Brain and behavior · 2026Article
- A brief historic overview of sexual and gender diversity in neuroscience: past, present, and future.Frontiers in human neuroscience · 2024Article
- Exploring sex differences: insights into gene expression, neuroanatomy, neurochemistry, cognition, and pathology.Frontiers in neuroscience · 2024Review
- The role of the pediatrician in the management of the child and adolescent with gender dysphoria.Italian journal of pediatrics · 2023Review
- Gender-affirming hormone therapy, mental health, and surgical considerations for aging transgender and gender diverse adults.Therapeutic advances in endocrinology and metabolism · 2023Review
- The Effects of Testosterone on the Brain of Transgender Men.Androgens: clinical research and therapeutics · 2021Review
- Characterization of theJournal of clinical medicine · 2021Article
- Cortical Gyrification in Transgender Individuals.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Cross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles.Scientific reports · 2021Observational
- Brain Sex Differences Related to Gender Identity Development: Genes or Hormones?International journal of molecular sciences · 2020Review
- Sex Matters: A Multivariate Pattern Analysis of Sex- and Gender-Related Neuroanatomical Differences in Cis- and Transgender Individuals Using Structural Magnetic Resonance Imaging.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Sex and Gender are Not the Same: Why Identity Is Important for People Living with HIV and Chronic Pain.Journal of pain research · 2020Article
- Cross sex hormone treatment is linked with a reversal of cerebral patterns associated with gender dysphoria to the baseline of cisgender controls.The European journal of neuroscience · 2019Article
- Possible Neurobiological Underpinnings of Homosexuality and Gender Dysphoria.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Making Sense of Connectivity.The international journal of neuropsychopharmacology · 2019Review
- What has sex got to do with it? The role of hormones in the transgender brain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Health considerations for transgender women and remaining unknowns: a narrative review.Therapeutic advances in endocrinology and metabolism · 2019Review
- Brief Report: Gender Identity Differences in Autistic Adults: Associations with Perceptual and Socio-cognitive Profiles.Journal of autism and developmental disorders · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Although previous investigations of transsexual people have focused on regional brain alterations, evaluations on a network level, especially those structural in nature, are largely missing. Therefore, we investigated the structural connectome of 23 female-to-male (FtM) and 21 male-to-female (MtF) transgender patients before hormone therapy as compared with 25 female and 25 male healthy controls. Graph theoretical analysis of whole-brain probabilistic tractography networks (adjusted for differences in intracranial volume) showed decreased hemispheric connectivity ratios of subcortical/limbic areas for both transgender groups. Subsequent analysis revealed that this finding was driven by increased interhemispheric lobar connectivity weights (LCWs) in MtF transsexuals and decreased intrahemispheric LCWs in FtM patients. This was further reflected on a regional level, where the MtF group showed mostly increased local efficiencies and FtM patients decreased values. Importantly, these parameters separated each patient group from the remaining subjects for the majority of significant findings. This work complements previously established regional alterations with important findings of structural connectivity. Specifically, our data suggest that network parameters may reflect unique characteristics of transgender patients, whereas local physiological aspects have been shown to represent the transition from the biological sex to the actual gender identity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.