Evidence map›Paper›PMID 25217053›Full record

ArticleGenetics2014

Differential regulation of germline apoptosis in response to meiotic checkpoint activation.

Alice L Ye, J Matthew Ragle, Barbara Conradt, Needhi Bhalla

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Male-specific roles of lincRNA inFrontiers in cell and developmental biology · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Phospho-Regulation of Meiotic Prophase.Frontiers in cell and developmental biology · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Alice L YeDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95060.
J Matthew RagleDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95060.
Barbara ConradtCenter for Integrated Protein Science, Department of Biology II, Ludwig Maximilians University, 82152 Munich, Germany.
Needhi BhallaDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95060 nbhalla@ucsc.edu.
University of California, Santa Cruz · USLudwig-Maximilians-Universität München · DE

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
The Synapsis Checkpoint in C. elegans MeiosisR01GM097144 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI BHALLA, NEEDHI · 2011 to 2020
$2.8M
NIGMS NIH HHS 1R01GM097144NIGMS NIH HHS R01 GM097144NIH HHS P40 OD010440
6 · The paper itself

Abstract

In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination.

Indexed as

ApoptosisCell Cycle CheckpointsMeiosisAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsChromosome PairingGerm CellsMutationRegulatory Sequences, Nucleic AcidTranscription, GeneticCaenorhabditis elegans ProteinsapoptosischeckpointDNA damagerecombinationsynapsis

Identifiers

PMID25217053
PMCPMC4224185
OpenAlexW2096015609

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.