ArticleHeart and vessels2016
Feasibility of tissue characterization of coronary plaques using 320-detector row computed tomography: comparison with integrated backscatter intravascular ultrasound.
Article in Heart and vessels, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Influencing factors and improvement methods of coronary artery plaque evaluation in CT.Frontiers in cardiovascular medicine · 2024Review
- Novel Imaging-Based Biomarkers for Identifying Carotid Plaque Vulnerability.Biomolecules · 2023Review
- Quantitative plaque characterisation and association with acute coronary syndrome on medium to long term follow up: insights from computed tomography coronary angiography.Cardiovascular diagnosis and therapy · 2022Article
- CD93 in macrophages: A novel target for atherosclerotic plaque imaging?Journal of cellular and molecular medicine · 2022Article
- Detecting vulnerable carotid plaque and its component characteristics: Progress in related imaging techniques.Frontiers in neurology · 2022Review
- Current Advances in the Diagnostic Imaging of Atherosclerosis: Insights into the Pathophysiology of Vulnerable Plaque.International journal of molecular sciences · 2020Review
- Article
- Impact of malondialdehyde-modified low-density lipoprotein on coronary plaque vulnerability in patients not receiving lipid-lowering therapy: a whole coronary analysis with multislice-computed tomography.Heart and vessels · 2018Article
- Coronary lesion characteristics with mismatch between fractional flow reserve derived from CT and invasive catheterization in clinical practice.Heart and vessels · 2017Article
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Authors and funding
9 authors.
Funding
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Abstract
Recently, a new generation of multi-detector row computed tomography (CT) with 320-detector rows (DR) has become available in the clinical settings. The purpose of the present study was to determine the cutoff values of Hounsfield unit (HU) for discrimination of plaque components by comparing HU of coronary plaques with integrated backscatter intravascular ultrasound (IB-IVUS) serving as a gold standard. Seventy-seven coronary atherosclerotic lesions in 77 patients with angina were visualized by both 320-DR CT (Aquilion One, Toshiba, Japan) and IB-IVUS at the same site. To determine the thresholds for discrimination of plaque components, we compared HU with IB values as a gold standard. Optimal thresholds were determined from receiver operating characteristic (ROC) curves analysis. The HU values of lipid pool (n = 115), fibrosis (n = 93), vessel lumen and calcification (n = 73) were 28 ± 19 HU (range -18 to 69 HU), 98 ± 31 HU (44 to 195 HU), 357 ± 65 HU (227 to 534 HU) and 998 ± 236 HU (366 to 1,489 HU), respectively. The thresholds of 56 HU, 210 HU and 490 HU were the most reliable predictors of lipid pool, fibrosis, vessel lumen and calcification, respectively. Lipid volume measured by 320-DR CT was correlated with that measured by IB-IVUS (r = 0.63, p < 0.05), whereas fibrous volume measured by 320-DR CT was not. Lipid volume measured by 320-DR CT was correlated with that measured by IB-IVUS, whereas fibrous volume was not correlated with that measured by IB-IVUS because manual exclusion of the outside of vessel hindered rigorous discrimination between fibrosis and extravascular components.
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