ArticleMetabolism: clinical and experimental2014
Subclinical albuminuria is linked to gray matter atrophy in type 2 diabetes mellitus.
Article in Metabolism: clinical and experimental, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Brain MRI Volume Findings in Diabetic Adults With Albuminuria: The ACCORD-MIND Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Trial
- Association between cerebral lesions and the severity of diabetic cardiovascular disease, retinopathy, and nephropathy-new lessons to learn from neuroimaging.Journal of endocrinological investigation · 2025Review
- A diagnosis model for brain atrophy using deep learning and MRI of type 2 diabetes mellitus.Frontiers in neuroscience · 2023Article
- Albuminuria as a risk factor for mild cognitive impairment and dementia-what is the evidence?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Review
- Identifying Type 2 Diabetic Brains by Investigating Disease-Related Structural Changes in Magnetic Resonance Imaging.Frontiers in neuroscience · 2021Article
- Altered Gray Matter Volume, Functional Connectivity, and Degree Centrality in Early-Onset Type 2 Diabetes Mellitus.Frontiers in neurology · 2021Article
- Poor self-rated health predicts the incidence of functional disability in elderly community dwellers in Japan: a prospective cohort study.BMC geriatrics · 2020Article
- Type 2 Diabetes Mellitus May Exacerbate Gray Matter Atrophy in Patients With Early-Onset Mild Cognitive Impairment.Frontiers in neuroscience · 2020Article
- The urine albumin-creatinine ratio is a predictor for incident long-term care in a general population.PloS one · 2018Article
- Disability of Hearing Impairment Is Positively Associated With Urine Albumin/Creatinine Ratio in Korean Adults: The 2011-2012 Korea National Health and Nutrition Examination Survey.Clinical and experimental otorhinolaryngology · 2016Article
- Differences in Factors Associated with Albuminuria according to Gender and Comorbidities of Hypertension and Diabetes.Korean journal of family medicine · 2015Article
- Factors Associated with Changes in Brain Atrophy during a Three-Year Observation in Elderly Diabetic Patients: Effect of Renal Impairment on Hippocampal Atrophy.Dementia and geriatric cognitive disorders extraArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveMicroalbuminuria (MA), a marker of renal microvascular disease, is associated with brain atrophy and neurovascular changes in older adults with type 2 diabetes mellitus (DM). We evaluated the relationship between urine albumin-to-creatinine ratio (UACR) and regional brain volumes to determine whether subclinical albuminuria may indicate early structural brain changes in type 2 DM. MATERIALS/
methodsWe studied UACR and brain volumes in 85 type 2 DM patients (64.8±8.3years) and 40 age-matched controls using 3D magnetization prepared rapid acquisition with gradient echo (MP-RAGE) MRI (magnetic resonance imaging) at 3 Tesla. The relationship between UACR and brain volumes was analyzed using the least square models.
resultsIn DM patients, UACR ≥5mg/g, UACR ≥10mg/g and clinically significant MA (UACR ≥17mg/g [males] and 25mg/g [females]) were associated with lower gray matter (GM) volume in the frontal lobe (r(2)adj=0.2-0.4, P=0.01-0.05) and UACR ≥5mg/g was also related to global GM atrophy (r(2)adj=0.1, P=0.04), independent of DM duration, glucose levels, HbA1c and hypertension. For UACR ≥5mg/g, a lower global GM volume was related to worse executive function (P=0.04) in the DM group. No associations were found for UACR (<5mg/g) and controls.
conclusionsSubclinical albuminuria (UACR ≥5mg/g) is associated with lower GM volume that has clinical impact on cognitive function in older diabetic patients, and these relationships are independent of DM control and hypertension. Therefore, UACR levels may serve as an additional marker of DM-related brain structural changes.
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